Pyrroloquinoline Quinone Disodium Salt (PQQ/CAS 122628-50-6) Powder
NutraJagen Pyrroloquinoline Quinone Disodium Salt is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Pyrroloquinoline Quinone Disodium Salt | Reddish-Brown Crystalline Powder | Active Assay ≥99.0% HPLC.
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Pyrroloquinoline Quinone Disodium Salt (CAS 122628-50-6) Bulk Supply
Pyrroloquinoline Quinone Disodium Salt (CAS 122628-50-6), chemically designated as disodium 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate, represents an essential redox-active o-quinone cofactor produced through advanced microbial fermentation using specialized Hyphomicrobium denitrificans strains. Synthetic alternatives often generate isomer impurities and organic solvent residues that compromise biological activity. NutraJagen enforces rigorous multi-stage crystallization and ion-exchange purification processes, guaranteeing an ultra-pure disodium salt matrix with HPLC active assays consistently exceeding 99.0%. Structural identity is validated via LC-MS and NMR analysis, confirming a exact molecular weight of 374.17 g/mol. Standard quinone compounds suffer from low aqueous dispersion, whereas our optimized crystalline salt form achieves rapid water solubility up to 30 g/L at 25°C. The material maintains structural integrity across elevated thermal processing and variable pH environments. This technical profile eliminates settling, color degradation, and potency loss in automated encapsulation lines, liquid shot batching, and topical anti-aging formulations. Global brand owners rely on this standardized raw material for consistent batch-to-batch bio-efficacy, seamless processing, and dependable regulatory compliance.
Core Health & Commercial Applications
Core Health & Physiological Mechanisms: Biochemical research confirms Pyrroloquinoline Quinone functions as a potent redox cofactor capable of executing continuous catalytic cycling—performing up to 20,000 catalytic transformations compared to roughly 4 for ascorbic acid. PQQ directly activates Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha (PGC-1α), stimulating mitochondrial biogenesis to increase cellular energy output in high-demand neural and cardiac tissues. Beyond mitochondrial renewal, PQQ upregulates Nerve Growth Factor (NGF) synthesis, protecting neuronal integrity and enhancing synaptic plasticity against neurotoxic stress. In dermal applications, PQQ quenches reactive oxygen species (ROS), neutralizes lipid peroxidation cascades, and preserves mitochondrial membrane potential in epidermal keratinocytes, effectively mitigating photoaging and cellular senescence.
Targeted Industry Applications: Formulators select specific active purities based on industrial processing equipment and final dosage delivery requirements. Primary commercial product lines include high-potency nootropic hard capsules, mitochondrial energy tablets, functional hydration beverages, liposomal liquid shots, anti-aging facial serums, and skin barrier repair emulsions.
Technical Specifications (TDS)
| Parameter | Specification Standard | Test Method |
|---|---|---|
| INCI / Chemical Name | Pyrroloquinoline Quinone Disodium Salt / Disodium PQQ | USP / INCI Index |
| CAS Registry Number | 122628-50-6 | CAS Index |
| Appearance | Reddish-Brown Crystalline Powder | Visual Inspection |
| Active Assay (PQQ Disodium) | ≥ 99.0% (On Dry Basis) | HPLC (External Standard) |
| Molecular Formula & Weight | C14H4N2Na2O8 | 374.17 g/mol | LC-MS / High-Res MS |
| Sodium Content | 11.5% – 13.0% | Ion Chromatography / AAS |
| Water Content (Karl Fischer) | 10.0% – 13.5% | USP <921> Method I |
| Heavy Metals Control | Total ≤ 10 ppm (Pb ≤ 1.0 ppm, As ≤ 1.0 ppm, Cd ≤ 0.5 ppm, Hg ≤ 0.1 ppm) | ICP-MS |
| Residual Solvents Control | Ethanol ≤ 5,000 ppm, Methanol ≤ 3,000 ppm, Acetone ≤ 5,000 ppm | GC-HS |
| Microbiological Profile | Total Plate Count < 1,000 cfu/g; Yeast & Mold < 100 cfu/g; Pathogens: Negative | USP <2021> / <2022> |
| Commercial Packaging | 1Kg Vacuum Sealed Aluminum Foil Bag / 25Kg Fiber Drum with Double PE Liners | Export Packaging Standard |
| Shelf Life | 24 Months stored in tight, light-resistant containers at temperature below 25°C | ICH Stability Protocol |
Formulation Processing Guidelines: Recommended daily dosage in dietary supplements ranges from 10 mg to 20 mg per serving. Topical cosmetic formulations incorporate PQQ Disodium Salt at concentrations between 0.01% and 0.1% by weight. Maintain formulation pH within a stable range of 3.0 to 7.5. PQQ exhibits strong thermal tolerance in dry environments up to 150°C, but liquid phase heating should remain below 80°C. Dissolve PQQ Disodium Salt directly into the aqueous phase prior to high-shear mixing or emulsification. Synergistic pairing with Coenzyme Q10, Alpha-GPC, or NMN enhances mitochondrial ATP output and cellular anti-aging performance.
Global Bulk Logistics Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Courier (DHL/FedEx) | < 50 kg | Higher Unit Cost | Door to Door delivery; 2–3 Days transit; Temperature-monitored insulation for evaluation samples and urgency pilot runs. |
| Air Freight Cargo | 50 kg – 500 kg | Moderate Freight Cost | Airport to Airport; 3–5 Days transit; Fast customs clearance for commercial production drums of PQQ Disodium Salt. |
| Ocean Sea Freight (FCL/LCL) | > 500 kg | Lowest Unit Freight Cost | Seaport to Seaport; 5–7 Days regional / 15–25 Days international transit; Climate-controlled containers available upon request. |
Technical & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients to support global cosmetic, nutraceutical, and pharmaceutical brands.
1. Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts, utilizing strain-engineered fermentation technology to ensure non-GMO, solvent-pure raw material inputs.
2. Quality Management: In-house testing facility combined with independent third-party verification ensures consistent batch compliance, executing HPLC chromatogram purity screening, heavy metal ICP-MS quantification, and microbial assays on every lot.
3. Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support, assisting formulation engineers with bio-availability enhancement, liposomal delivery, and oil-water phase stability challenges.
4. Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation, providing complete regulatory files, COAs, MSDS dossiers, and technical customs clearance support.
Technical & Commercial FAQ
What is the Minimum Order Quantity (MOQ) for high-purity Pyrroloquinoline Quinone Disodium Salt?
Our minimum order quantity starts at 1Kg packaged in vacuum-sealed aluminum foil bags for pilot testing and formula validation. Standard commercial orders ship in 25Kg fiber drums.
What bulk lead time applies to commercial production quantities?
Active warehouse reserves hold 1,000Kg to 2,000Kg of standardized stock for immediate dispatch within 48 hours. Custom particle milling or specialized packaging configurations require 7 to 10 business days.
How stable is PQQ Disodium Salt under variable temperature and light exposure?
PQQ Disodium Salt maintains structural stability in solid form up to 150°C. Because it is light-sensitive, raw material containers should remain sealed in amber or opaque packaging shielded from direct UV exposure.
Which quality documentation accompanies each commercial batch shipment?
Every shipment includes a full Certificate of Analysis (COA) specifying HPLC active assay purity, Heavy Metal ICP-MS data, Residual Solvent GC metrics, MSDS, and accredited ISO22000, HACCP, and HALAL certifications.
Can NutraJagen supply pre-dissolved liquid solutions or customized particle sizes?
Yes. We offer micro-milled powder specifications tailored for rapid dissolution and can support custom aqueous masterbatches or OEM premixes designed for high-speed liquid filling lines.
Request Factory-Direct Quotation & Pilot Samples
Contact our technical sales team directly to receive tiered volume pricing, review batch HPLC analytical dossiers, and arrange immediate laboratory sample evaluation.
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