Nicotinamide Adenine Dinucleotide (NAD+ / CAS 53-84-9)
NutraJagen Nicotinamide Adenine Dinucleotide is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Nicotinamide Adenine Dinucleotide / CAS 53-84-9 | White to Off-White Powder | Purity ≥98.0% (HPLC).
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Nicotinamide Adenine Dinucleotide (CAS 53-84-9) ≥98.0%
Product Introduction
Nicotinamide Adenine Dinucleotide (CAS 53-84-9) functions as an essential pyridine nucleotide coenzyme governing cellular bioenergetics and redox homeostasis across all living metabolic systems. Industrial synthesis relies on advanced enzymatic biocatalysis, yielding the biologically active beta-anomer while restricting inactive alpha-isomer impurities below 0.5%. Bulk handling often exposes raw materials to rapid hydrolytic breakdown into adenosine monophosphate and nicotinamide under improper ambient humidity. Lyophilized crystallization under low-temperature processing preserves a crisp crystalline matrix with HPLC assay purities strictly verified at or above 98.0%. Water solubility exceeding 50 mg/mL allows seamless incorporation into sublingual powders, liposomal liquid complexes, and advanced dermal delivery suspensions. Low ambient humidity controls below 35% RH during processing protect powder bulk density and prevent clumping during rapid capsule filling. Standardized coenzyme purity provides global formulation brands with reproducible kinetic performance, verifiable batch stability, and dependable scale-up security.
Core Functionality & Targeted Applications
Core Health & Biological Functionality:
Redox reactions depend fundamental cellular machinery upon the reversible hydride exchange between NAD+ and NADH. Oxidation of metabolic substrates drives ATP generation within the inner mitochondrial membrane via oxidative phosphorylation. Beyond metabolic hydride transfer, NAD+ acts as a consumed substrate for sirtuin deacetylases (SIRT1-SIRT7) and poly(ADP-ribose) polymerases (PARPs). Sirtuin activation modulates mitochondrial biogenesis, nuclear gene expression, and epigenetic chromatin remodeling. PARP enzymes consume intracellular NAD+ pools to execute single-strand DNA break repair during environmental or oxidative cellular stress. Exogenous supplementation replenishes age-dependent coenzyme depletion across vascular, neuronal, and dermal tissues. Applied topically, NAD+ accelerates keratinocyte ATP turnover, enhances collagen type I synthesis, and suppresses ultraviolet-induced mitochondrial DNA damage within the cutaneous barrier.
Targeted Industry Applications:
- Cellular Longevity & Anti-Aging Dietary Supplements: Formulated into delayed-release capsules, sublingual tablets, and oral liposomal gels targeting systemic coenzyme restoration.
- Mitochondrial Bioenergetic Blends: Combined with co-factors like coenzyme Q10 and resveratrol in elite sports nutrition and cognitive enhancement products.
- Advanced Barrier Repair & Topical Serums: Integrated into low-pH facial serums, lipid emulsions, and post-procedure dermatological recovery creams.
- Nutraceutical Dry Powder Sachet Systems: Prepared inside moisture-impermeable sachet packaging designed for immediate aqueous reconstitution prior to ingestion.
Technical Data Sheet (TDS) & Processing Parameters
| Parameter | Specification Standard | Testing Method |
|---|---|---|
| Chemical Name / INCI | Nicotinamide Adenine Dinucleotide / Nicotinamide Adenine Dinucleotide | IUPAC Identification |
| CAS Number | 53-84-9 | Chemical Registry Index |
| Appearance | White to Off-White Powder | Visual Inspection |
| Assay (Purity) | ≥ 98.0% (Beta-Anomer; Alpha-Isomer ≤ 0.5%) | RP-HPLC |
| Molecular Weight (MW) | 663.43 Da | Mass Spectrometry (MS) |
| Heavy Metals (Total) | ≤ 10 ppm (Pb ≤ 2ppm, As ≤ 1ppm, Cd ≤ 1ppm, Hg ≤ 0.1ppm) | ICP-MS |
| Residual Solvents | Ethanol ≤ 5000 ppm; Methanol ≤ 100 ppm; Acetone ≤ 500 ppm | GC-Headspace |
| Microbiological Limits | Total Plate Count ≤ 1,000 cfu/g; Yeast & Mold ≤ 100 cfu/g; Salmonella Negative | USP <61/62> / AOAC |
| Commercial Packaging | 1kg/Vacuum Sealed Foil Bag; 25kg/Fiber Drum with Dual PE Liners | Export Sealed Standard Packaging |
| Shelf Life | 24 Months Stored at -20°C to 4°C Sealed Away from Moisture and Light | Real-Time Stability Testing |
Formulation & Processing Directives
- Recommended Dosage: 50 mg to 250 mg daily in dietary supplement formulations; 0.1% to 1.0% w/w in topical cosmetic emulsions.
- Thermal Processing Window: Heat exposure during manufacturing must not exceed 40°C. Prolonged thermal stress accelerates cleaving of the pyrophosphate linkage.
- Optimal pH Stability Range: Formulations perform best between pH 4.0 and pH 6.0. Rapid cleavage occurs in strong acidic (<3.0) or basic (>7.5) media.
- Handling Environment: Processing suites require relative humidity controlled under 35% RH to eliminate atmospheric moisture uptake and powder caking.
Global Logistics & Matrix Distribution
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Air Freight (DHL/FedEx/UPS) | Ideal for <50 kg | Higher Cost Per Kg | Door-to-door expedited delivery within 2 to 3 business days. Packaged in temperature-insulated cold foil shippers with gel ice packs to ensure enzymatic integrity. |
| Standard Air Cargo | Optimal for >50 kg | Moderate Cost | Airport-to-airport transit within 3 to 5 business days. Efficient scheduling for high-value commercial orders with cold-chain storage logging available. |
| Ocean Freight (FCL/LCL Container) | Preferred for >500 kg | Highly Economical | Seaport-to-seaport bulk transport taking 5 to 7 days regionally. Shipped in reefer containers controlled at 2°C–8°C to prevent thermal degradation over water routes. |
Technical Capabilities & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, leveraging advanced fermentation platforms and chemical purification infrastructure with a broad portfolio covering thousands of plant extract ingredients and bio-identical coenzyme actives. Precision enzymatic reaction control ensures tight stereospecificity, guaranteeing minimal isomeric contamination and consistent catalytic reactivity in every manufacturing lot.
Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts.
Quality Management: In-house testing facility combined with independent third-party verification to ensure consistent batch compliance.
Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support.
Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation.
Frequently Asked Questions
What is the minimum order quantity (MOQ) for Nicotinamide Adenine Dinucleotide?
Commercial MOQ starts at 1 kg packed in a vacuum foil bag. Pilot laboratory evaluation samples from 100 g to 1 kg are supplied upon commercial inquiry.
What standard fulfillment lead times apply to commercial order orders?
Standard warehouse stock maintaining 1,000 kg to 2,000 kg dispatches in 3 to 5 business days. Contract manufacturing runs require 10 to 14 business days from order confirmation.
How does NutraJagen protect NAD+ powder against moisture and temperature stress?
Packaging occurs under relative humidity below 35%. Material is sealed in double PE inner bags housed inside heavy aluminum foil pouches with desiccant packs, shipped in temperature-controlled boxes when required.
Which analytical testing reports accompany bulk raw material deliveries?
Each batch includes a full Certificate of Analysis (COA) specifying HPLC purity, optical rotation, residual solvents via GC-HS, ICP-MS heavy metals, microbial counts, and MSDS safety protocols.
Can NutraJagen assist with custom particle sizing or aqueous solution OEM premixes?
Yes, custom particle size reduction via jet milling, dry blend formulation support, and client-specific private-label packaging are available under contract manufacturing terms.
Request Bulk Quotation & Technical Documentation
Access direct factory pricing, batch COAs, and technical evaluation samples. Our engineering and sales teams respond within 12 business hours.
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