L-Glutathione Reduced (GSH / CAS 70-18-8)
NutraJagen L-Glutathione Reduced is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Glutathione | White Crystalline Powder | Assay ≥98.0% (HPLC/Titration).
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
L-Glutathione Reduced (GSH / CAS 70-18-8) Powder ≥98.0% Manufacturer
NutraJagen L-Glutathione Reduced is an endogenous low-molecular-weight tripeptide (gamma-L-glutamyl-L-cysteinyl-glycine) produced through advanced enzymatic bio-fermentation, yielding an ultra-pure bioactive crystal meeting a strict specification assay of ≥98.0%. High aqueous solubility guarantees immediate dissolution during liquid phase compounding without leaving cloudy residues or persistent particulate suspensions. Advanced crystallization control limits oxidized glutathione (GSSG) impurities below 1.0% while keeping heavy metal totals strictly under 10 ppm. High chemical purity allows seamless integration into sublingual tablets, liposomal oral liquids, hard gelatin capsules, and anti-melanogenic topical creams. Precise redox activity control prevents premature oxidation during bulk storage and formulation blending phases. Delivering consistent molecular integrity across production runs equips commercial brand owners with quantifiable formula efficacy, extended shelf stability, and verified technical compliance.
Core Functional Mechanisms & Target Formulations
1. Core Health/Functional Benefits
Tyrosinase Inhibition & Melanogenesis Shift: The active thiol moiety chelates copper ions at the catalytic site of tyrosinase, blocking enzymatic DOPA oxidation. Binding reactive dopaquinone intermediates directs the biochemical pathway toward lighter pheomelanin synthesis rather than darker eumelanin polymers.
Phase II Hepatic Conjugation & Cellular Detoxification: Serves as the substrate for glutathione S-transferase (GST) enzymes in hepatocyte cytoplasm. Conjugating electrophilic xenobiotics, heavy metals, and lipid hydroperoxides renders toxic metabolites water-soluble for renal excretion.
Endogenous Antioxidant Network Regeneration: High nucleophilic capacity quenches reactive oxygen species (ROS) and hydroxyl radicals directly. Transferring hydrogen atoms recycles oxidized alpha-tocopherol and ascorbic acid back into active antioxidant states within mitochondrial membranes.
2. Targeted Industry Applications
Nutricosmetic Skin Brightening Capsules: Formulated into oral dietary supplements, liposomal softgels, and effervescent tablets designed to decrease melanin index scores and improve facial radiance.
Hepatic Health & Detoxification Blends: Combined with milk thistle extract, N-acetyl-L-cysteine, and alpha-lipoic acid in targeted liver support and hangover recovery supplements.
Advanced Anti-Pigmentation Serums: Integrated into topical aqueous treatments, localized spot correctors, and post-laser recovery fluids to suppress hyperpigmentation cascades.
Cellular Longevity & Immune Beverages: Blended into functional wellness shots and powder stickpacks targeted at mitochondrial protection and systemic oxidative stress reduction.
Technical Data Sheet (TDS) & Operational Guidelines
| Parameter | Specification Standard | Test Method |
|---|---|---|
| INCI / Chemical Name | Glutathione / L-Glutathione Reduced | Standard Nomenclature |
| CAS Number | 70-18-8 | CAS Index |
| Appearance | White crystalline powder | Visual Inspection |
| Assay (Purity) | ≥98.0% (GSSG ≤ 1.0%) | HPLC / Iodometric Titration |
| Molecular Weight (MW) | 307.32 g/mol | MS / Calculation |
| Heavy Metals Control | Total ≤ 10 ppm (Pb ≤ 2 ppm, As ≤ 1 ppm) | ICP-MS |
| Residual Solvents | Meets international pharmaceutical & food limits | GC-HS |
| Microbiological Profile | Total Plate Count < 1,000 CFU/g; Pathogens Negative | USP / EP Standard |
| Commercial Packaging | 1kg/vacuum aluminum foil bag, 25kg/fiber drum with double PE liners | Standard Export Packaging |
| Shelf Life | 24 Months stored in sealed containers protected from air and light at 2°C–8°C | Stability Testing |
Formulation & Operational Guidelines
- Recommended Addition Dosage: Oral nutricosmetic formulations require 100mg–500mg daily; topical skincare applications recommend 0.2%–2.0%.
- Processing Heat Stability: Thermal exposure degrades the active thiol group rapidly. Add GSH below 40°C during late cooling phases in topical emulsions, or employ low-temperature dry blending for solid dose oral manufacturing.
- Optimal pH Range: Aqueous formulations require pH 3.0–5.5 to minimize thiol oxidation. Avoid alkaline conditions (pH > 6.5) which accelerate conversion into inactive oxidized glutathione (GSSG).
- Oxidative Stabilization Protocols: Incorporate 0.05%–0.1% disodium EDTA or citric acid as metal chelators to prevent trace iron or copper ions from catalyzing autoxidation. Pair with Vitamin C or Vitamin E for synergetic redox maintenance.
Global B2B Supply Chain & Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Courier (DHL/FedEx/UPS) | < 50kg | Premium Speed, Higher Cost | Door to Door delivery; transit time 2-3 business days. Vacuum foil packaging with desiccant inserts prevents moisture and oxygen degradation during air transit. |
| Air Freight | > 50kg | Moderate Freight Cost | Airport to Airport delivery; transit time 3-5 business days. Optimal balance between rapid arrival and commercial freight economy for high-value bio-actives. |
| Sea Cargo | > 500kg | Lowest Unit Freight Cost | Seaport to Seaport delivery; transit time 5-7 days (regional) or 15-30 days (global). Temperature-controlled reefer containers allocated for volume shipments to ensure temperature stability. |
Manufacturing Infrastructure & Corporate Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients and specialized bio-fermented peptides engineered for global health and beauty brands.
Natural Solutions: Focus on bio-fermented ingredients and natural cellular actives aligned with clean, sustainable, and health-oriented international formulation concepts.
Quality Management: In-house testing facility equipped with HPLC, LC-MS, and ICP-MS instrumentation combined with independent third-party analytical verification to guarantee batch consistency.
Professional Team: Skilled commercial and technical teams providing proactive formulation advice, regulatory documentation, and responsive R&D support for complex application challenges.
Customer Support: End-to-end service team maintaining close follow-up from preliminary sample testing to bulk shipment delivery and post-market compliance updates.
Frequently Asked Questions (Technical & B2B Sourcing)
What minimum order quantity (MOQ) applies to L-Glutathione Reduced bulk shipments?
The minimum order quantity for commercial evaluations starts at 1kg packaged in a vacuum-sealed aluminum foil bag. Bulk commercial consignments ship in standard 25kg fiber drums lined with double PE moisture-barrier bags.
What dispatch timeline is expected for 500kg or larger commercial orders?
Active warehouse stock between 1,000kg and 2,000kg guarantees dispatch within 48 hours for standard lots. Custom batch synthesis or specialized particle size processing requiring volumes above 500kg takes 7 to 10 business days.
How is oxidation prevented during aqueous solution processing and storage?
Glutathione oxidizes rapidly in aqueous environments above pH 6.0 or under high thermal exposure. Formulators must maintain processing pH between 3.0 and 5.5, incorporate chelating agents like disodium EDTA, and keep processing temperatures under 40°C during final phase addition.
Does NutraJagen supply compliance certification for regulatory registration in global markets?
Every batch arrives with a complete Certificate of Analysis (COA), MSDS, ISO22000, HACCP, and HALAL documentation. Third-party testing records verifying heavy metal limits, residual solvents, and microbiological safety are supplied upon request.
Are liposomal blends, customized particle mesh sizes, or OEM liquid preparations supported?
NutraJagen provides tailored particle micronization, liposomal masterbatch premixes, and customized unit packaging configurations based on technical review of formulation specifications.
Request Commercial Quote & Free Pilot Samples
Access competitive factory bulk pricing, download complete regulatory technical dossiers, and order laboratory-grade pilot samples for your nutricosmetic or dietary supplement lines.
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