Coenzyme Q10 Ubiquinone CoQ10/CAS 303-98-0 Powder
NutraJagen Coenzyme Q10 is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Ubiquinone / Coenzyme Q10 | Yellow to Orange Crystalline or Water-Dispersible Powder | Active Assay 10% CWD / ≥98.0% USP.
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Coenzyme Q10 Ubiquinone (CAS 303-98-0) Bulk Supply
Coenzyme Q10 (CAS 303-98-0), chemically known as 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-nonamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione or Ubiquinone, functions as an essential lipophilic benzoquinone synthesized via state-of-the-art bacterial fermentation using Rhodobacter sphaeroides strain optimization. Conventional synthetic routes suffer from cis-isomer byproducts that degrade physiological bio-efficacy. NutraJagen enforces strict multi-stage crystallization and solvent extraction protocols, guaranteeing a pure all-trans isomer profile exceeding 98.0% purity alongside microencapsulated 10% Cold Water Dispersible (CWD) grades. Structural verification via HPLC and FT-IR confirms precise molecular weight matching at 863.34 g/mol. Standard lipophilic CoQ10 crystals exhibit severe dissolution barriers in aqueous digestive fluids, limiting oral bioavailability. Our proprietary spray-drying CWD technology coats hydrophobic quinone nuclei inside food-grade starch matrixes. Particle size distribution stays strictly below 5 microns. This physical architecture solves phase separation, oil slicking, and thermal degradation risks across softgel suspension tanks, beverage pasteurization loops, and topical emulsion homogenizers. Formulators seamlessly integrate these active grades into cardiovascular health softgels, mitochondrial energy capsules, functional hydration stick packs, and advanced dermal barrier restoration creams. Standardized lot-to-lot consistency guarantees global brand owners strict compliance, predictable kinetics, and long-term brand market security.
Core Health & Commercial Applications
Core Health & Physiological Mechanisms: Biochemical research confirms Coenzyme Q10 functions as a required electron carrier within complexes I, II, and III of the mitochondrial inner membrane electron transport chain. ATP synthase activation directly depends on Ubiquinone density. Cellular bioenergetics accelerate under sustained Q-cycle oxidation. Beyond metabolic energy shuttling, reduced Ubiquinol acts as a potent lipid-phase chain-breaking antioxidant. Myocardial tissue maintains elevated mitochondrial density; CoQ10 supplementation mitigates oxidative damage to membrane phospholipids, suppresses low-density lipoprotein (LDL) peroxidation, and supports healthy endothelial vascular tone. In dermal layers, localized Ubiquinone inhibits UV-induced matrix metalloproteinase-1 (MMP-1) expression, preventing structural collagen cleavage and protecting epidermal keratinocyte bioenergetics.
Targeted Industry Applications: Formulators select specific active purities based on industrial processing equipment and final dosage delivery requirements. Primary commercial product lines include softgel capsules filled with lipid-suspended 98% crystalline powder, hard-shell dietary capsules combined with lipid carriers, functional hydration beverages utilizing 10% CWD water-soluble powder, anti-aging facial serums, and firming eye contour repair creams.
Technical Specifications (TDS)
| Parameter | Specification Standard | Test Method |
|---|---|---|
| INCI / Chemical Name | Ubiquinone / Coenzyme Q10 | USP / INCI Index |
| CAS Registry Number | 303-98-0 | CAS Index |
| Appearance | Yellow-Orange Crystalline Powder (98%) / Fine Light Yellow Powder (10% CWD) | Visual Inspection |
| Active Assay (CoQ10) | ≥ 98.0% (USP Grade Crystalline) / ≥ 10.0% (CWD Water-Soluble) | HPLC (USP Monograph) |
| Molecular Formula & Weight | C59H90O4 | 863.34 g/mol (All-trans Isomer) | Mass Spectrometry / FT-IR |
| Melting Point Range | 48.0°C – 52.0°C (Pure Crystalline Grade) | Capillary Melting Method |
| Chromatographic Impurities | Coenzyme Q9 ≤ 1.0%; Related Ubiquinone Substances Total ≤ 1.5% | HPLC Analysis |
| Heavy Metals Control | Total ≤ 10 ppm (Pb ≤ 1.0 ppm, As ≤ 1.0 ppm, Cd ≤ 0.5 ppm, Hg ≤ 0.1 ppm) | ICP-MS |
| Residual Solvents Control | Ethanol ≤ 5,000 ppm, Hexane ≤ 290 ppm, Acetone ≤ 5,000 ppm | GC-HS |
| Microbiological Profile | Total Plate Count < 1,000 cfu/g; Yeast & Mold < 100 cfu/g; Pathogens: Negative | USP <2021> / <2022> |
| Commercial Packaging | 1Kg Vacuum Sealed Foil Bag / 25Kg Cardboard Drum with Double Inner PE Liners | Export Packaging Standard |
| Shelf Life | 24 Months stored in tight, light-resistant containers at temperature below 20°C | ICH Stability Protocol |
Formulation Processing Guidelines: Recommended oral intake ranges from 30 mg to 200 mg daily for standard dietary dietary supplements. Topical skincare formulations incorporate 98% pure crystalline powder at 0.05% to 0.5% active concentration. Maintain formula pH within a stable 4.5 to 7.0 window. Processing temperatures must stay below 50°C to prevent thermal quinone degradation. Dissolve lipophilic 98% crystalline powder into oil phase lipids or medium-chain triglycerides (MCT oil) prior to high-shear emulsification. Incorporate 10% CWD powder into the aqueous phase below 40°C during final beverage or gel blending.
Global Bulk Logistics Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Courier (DHL/FedEx) | < 50 kg | Higher Unit Cost | Door to Door delivery; 2–3 Days transit; Temperature-monitored insulation for evaluation samples and urgency pilot runs. |
| Air Freight Cargo | 50 kg – 500 kg | Moderate Freight Cost | Airport to Airport; 3–5 Days transit; Fast customs clearance for commercial production drums of 98% and 10% CWD. |
| Ocean Sea Freight (FCL/LCL) | > 500 kg | Lowest Unit Freight Cost | Seaport to Seaport; 5–7 Days regional / 15–25 Days international transit; Climate-controlled reefer containers available upon request. |
Technical & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients to support global cosmetic, nutraceutical, and pharmaceutical brands.
1. Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts, utilizing strain-engineered fermentation technology to ensure non-GMO, solvent-pure raw material inputs.
2. Quality Management: In-house testing facility combined with independent third-party verification ensures consistent batch compliance, executing HPLC chromatogram purity screening, heavy metal ICP-MS quantification, and microbial assays on every lot.
3. Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support, assisting formulation engineers with bio-availability enhancement, liposomal delivery, and oil-water phase stability challenges.
4. Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation, providing complete regulatory files, COAs, MSDS dossiers, and technical customs clearance support.
Technical & Commercial FAQ
What is the Minimum Order Quantity (MOQ) for high-purity USP grade Coenzyme Q10?
Both 98% pure crystalline powder and 10% CWD water-soluble powder feature a minimum order quantity of 1Kg in vacuum-sealed aluminum bags for pilot testing. Standard commercial orders ship in 25Kg fiber drums.
What bulk lead time applies to large production quantities?
Active warehouse reserves hold 1,000Kg to 2,000Kg of standardized stock for immediate dispatch within 48 hours. Custom particle milling or microencapsulated beverage runs require 7 to 10 working days.
How stable is Coenzyme Q10 against ambient thermal heating and oxidation?
Crystalline CoQ10 melts between 48°C and 52°C and degrades under prolonged thermal stress above 65°C. Formulators should store raw drums below 20°C in light-shielded containers and maintain processing temperatures under 50°C.
Which quality documentation accompanies each commercial batch shipment?
Every shipment includes a full Certificate of Analysis (COA) specifying HPLC all-trans assay purity, Heavy Metal ICP-MS data, Residual Solvent GC metrics, MSDS, and accredited ISO22000, HACCP, and HALAL certificates.
Can NutraJagen supply pre-dispersed OEM liquid emulsions or microencapsulated stick packs?
Yes. We offer microencapsulated 10% CWD powders optimized for instant cold-water dissolution without oil separation, as well as customized lipid suspension masterbatches designed for high-speed softgel encapsulation lines.
Request Factory-Direct Quotation & Pilot Samples
Contact our technical sales team directly to receive tiered volume pricing, review batch HPLC analytical dossiers, and arrange immediate laboratory sample evaluation.
Inquire via Email
We would love to speak with you.
Feel free to reach out using the below details.