Acetyl Hexapeptide-38 (Adifyline / CAS 1400634-77-7)
NutraJagen Acetyl Hexapeptide-38 is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Acetyl Hexapeptide-38 | White to Off-White Crystalline Powder | Assay ≥98.0% (HPLC).
📦 MOQ & Packaging: Min Order 0.01Kg | Standard 10g 100g 1Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 10Kg–20Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Acetyl Hexapeptide-38 (CAS 1400634-77-7) Powder ≥98.0% Manufacturer
NutraJagen Acetyl Hexapeptide-38 is a synthetically engineered target peptide synthesized via automated solid-phase peptide protocols to consistently yield an assay purity of ≥98.0% by HPLC. Molecular sequence design selectively targets human peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) to stimulate localized preadipocyte differentiation and lipid accumulation. Preparative reverse-phase liquid chromatography removes truncated peptide sequences, keeping individual related substances under 1.0% while eliminating residual halogenated solvents. High water solubility and excellent glycol compatibility allow rapid cold-process dispersion without requiring heating cycles or aggressive surfactant matrices. Formulators integrate this peptide into facial contouring serums, lip-plumping treatments, bust-enhancing emulsions, and targeted anti-aging formulations addressing age-related structural fat loss. Global cosmetic manufacturers rely on this standardized raw material for repeatable batch-to-batch biological potency, superior solution clarity, and exceptional shelf stability across complex emulsion networks.
Core Functional Mechanisms & Target Formulations
1. Core Health/Functional Benefits
PGC-1alpha Expression Upregulation: Enhances PGC-1alpha transcription rate in subcutaneous preadipocytes. Elevated coactivator levels accelerate cellular maturation into functional, lipid-accumulating adipocytes.
Adipogenesis & Triglyceride Storage Stimulation: Increases intracellular lipid droplet formation without triggering systemic hormonal side effects. Higher localized fat cell volume restores youthful facial contours and fills out sunken temporal or cheek zones.
Subcutaneous Layer Volume Enhancement: Structural expansion of the subcutaneous adipose tissue layer redensifies sagging skin from within. Topically delivered active peptide restores lost physical volume to smooth deep facial folds.
2. Targeted Industry Applications
Facial Contouring & Plumping Serums: Formulated into light aqueous treatments at 0.005%–0.01% pure peptide (or 2.0%–5.0% of a 500 ppm liquid stock) to target sunken cheeks, hollow tear troughs, and deep nasolabial grooves.
Non-Invasive Lip Volume Enhancers: Blended into lip care balms and glosses to increase local vermilion border volume and smooth fine perioral vertical lines.
Targeted Bust & Decollete Emulsions: Blended into body creams aimed at increasing local adipose volume and improving firmness across the bust area.
Restorative Hand Anti-Aging Creams: Integrated into nourishing hand treatments to replenish subcutaneous fat padding, minimizing visible dorsal veins and tendons.
Technical Data Sheet (TDS) & Operational Guidelines
| Parameter | Specification Standard | Test Method |
|---|---|---|
| INCI Name | Acetyl Hexapeptide-38 | Standard Nomenclature |
| CAS Number | 1400634-77-7 | CAS Index |
| Appearance | White to off-white crystalline powder | Visual Inspection |
| Assay (Peptide Purity) | ≥98.0% (Single Impurity ≤ 1.0%) | HPLC |
| Molecular Weight (MW) | ~612.68 g/mol | MS / ESI |
| Heavy Metals Control | Total ≤ 10 ppm (Pb ≤ 2 ppm, As ≤ 1 ppm, Cd ≤ 1 ppm) | ICP-MS |
| Residual Solvents | Acetonitrile ≤ 410 ppm, Trifluoroacetic Acid ≤ 0.5% | GC-HS / HPLC |
| Microbiological Profile | Total Plate Count < 100 CFU/g; Pathogens Negative | USP / EP Standard |
| Commercial Packaging | 1kg/vacuum aluminum foil bag, 25kg/fiber drum with dual PE liners | Standard Export Packaging |
| Shelf Life | 24 Months stored in sealed containers protected from light at 2°C–8°C | Stability Testing |
Formulation & Operational Guidelines
- Recommended Dosage: Pure active powder: 0.005%–0.01% (50 ppm to 100 ppm); Standard liquid masterbatch (0.05% solution): 2.0%–5.0% in finished commercial formulations.
- Processing Temperature Range: High thermal exposure breaks peptide backbone chains. Maintain batch temperatures below 40°C during formulation. Incorporate during post-emulsification cooling phases.
- Optimal pH Range: Demonstrates peak stability between pH 5.0 and 7.5. Avoid extreme acidic environments below pH 4.0 or alkaline conditions above pH 8.0.
- Solubility & Phase Compatibility: Dissolves readily in the aqueous phase or water-glycerin mixtures. Compatible with hyaluronic acid, non-ionic emulsifiers, polyols, and structural signaling peptides. Avoid strong oxidizing agents and unchelated heavy metal salts.
Global B2B Supply Chain & Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Courier (DHL/FedEx/UPS) | < 50kg | Premium Speed, Higher Cost | Door to Door delivery; transit time 2-3 business days. Gel-pack temperature insulation protects peptide structural integrity during express transport. |
| Air Freight | > 50kg | Moderate Freight Cost | Airport to Airport delivery; transit time 3-5 business days. Rapid air transit suited for medium-scale manufacturing schedules. |
| Sea Cargo | > 500kg | Lowest Unit Freight Cost | Seaport to Seaport delivery; transit time 5-7 days (regional) or 15-30 days (global). Climate-controlled reefer containers maintain target temperatures during sea passage. |
Manufacturing Infrastructure & Corporate Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients, cosmetic neuropeptides, and bio-functional actives engineered for global personal care and health industries.
Natural Solutions: Focus on plant-based ingredients and clean-label bioactive peptide structures aligned with modern, sustainable international concepts.
Quality Management: In-house testing facility equipped with LC-MS, HPLC, and ICP-MS combined with independent third-party verification to ensure batch compliance.
Professional Team: Skilled commercial and technical teams offering proactive formulation guidance and responsive R&D support for complex cosmetic applications.
Customer Support: End-to-end service team maintaining close tracking from initial inquiry through order dispatch to ensure long-term commercial cooperation.
Frequently Asked Questions (Technical & B2B Sourcing)
What minimum order quantity (MOQ) applies to Acetyl Hexapeptide-38 bulk orders?
Pilot trial runs start at 0.01kg contained in vacuum-sealed aluminum foil pouches padded under inert gas. Commercial scale purchases transition into standard 1kg export-grade fiber drums fitted with double polyethylene liner bags.
What dispatch lead time governs industrial orders exceeding 10kg?
Factory floor reserves maintain 10kg to 20kg active stock ready for immediate dispatch within 48 hours. Orders requiring custom liquid masterbatches or special packaging dispatch within 7 to 10 business days.
How does Acetyl Hexapeptide-38 selectively promote localized lipid accumulation?
Targeted upregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) accelerates preadipocyte differentiation into mature adipocytes. Higher functional adipocyte counts drive intracellular triglyceride storage, expanding subcutaneous fat layer thickness.
Which quality documentation accompanies each dispatched batch from NutraJagen?
Every batch dispatches with an official Certificate of Analysis (COA), Safety Data Sheet (MSDS), ISO22000, HACCP, and HALAL certifications. Third-party testing records detailing HPLC purity, residual trifluoroacetic acid (TFA), and heavy metals are furnished on request.
Does NutraJagen supply pre-dissolved liquid stock solutions alongside raw powder?
NutraJagen produces customized liquid stock solutions, including standard 0.05% (500 ppm) or 0.1% (1,000 ppm) aqueous or glycolic masterbatches engineered for direct cold-process addition.
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