Nicotinamide Riboside Chloride (NR-Cl / CAS 23111-00-4)
NutraJagen Nicotinamide Riboside Chloride is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Nicotinamide Riboside Chloride / CAS 23111-00-4 | White to Off-White Crystalline Powder | Purity ≥98.0% (HPLC).
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Nicotinamide Riboside Chloride (CAS 23111-00-4) ≥98.0%
Product Introduction
Nicotinamide Riboside Chloride (CAS 23111-00-4) represents a crystalline pyridinium nucleoside salt operating as a direct biological precursor to nicotinamide adenine dinucleotide (NAD+). Commercial raw material streams routinely face degradation risks triggered by trace hydrolysis into nicotinamide and D-ribose under ambient moisture exposure. Controlled crystallization under inert nitrogen blanketing yields a crystalline lattice maintaining HPLC purity consistently above 98.0% with free nicotinamide impurities restricted below 1.0%. High aqueous solubility exceeding 100 mg/mL enables smooth processing across solid dose oral capsules, two-piece hard gelatin matrices, and topical barrier-repair formulations. Processing operations require low relative humidity parameters below 40% to preserve powder flowability during high-speed tableting or encapsulation runs. Standardized crystalline purity equips global brand owners with verified structural stability, predictable bioavailability profiles, and dependable scale-up manufacturing performance.
Core Functionality & Targeted Applications
Core Health & Biological Functionality:
Phosphorylation via nicotinamide riboside kinases (NRK1 and NRK2) converts Nicotinamide Riboside directly into Nicotinamide Mononucleotide (NMN), bypassing the rate-limiting NAMPT enzyme step in the NAD+ salvage pathway. Elevated intracellular NAD+ concentrations drive mitochondrial oxidative phosphorylation by serving as a mandatory electron co-factor for complex I and complex III within the electron transport chain. Enzymatic activation of sirtuin deacetylases (SIRT1, SIRT3) and poly(ADP-ribose) polymerases (PARPs) enhances mitochondrial biogenesis, repairs damaged genomic DNA strands, and mitigates intracellular oxidative stress. Clinical kinetic data confirms significant serum NAD+ elevation following oral administration without triggering the cutaneous flushing associated with high-dose nicotinic acid. Dermal target tissue applications demonstrate improved keratinocyte energy dynamics, enhanced filaggrin expression, and accelerated recovery of disrupted epidermal lipid barriers.
Targeted Industry Applications:
- Cellular Longevity & Anti-Aging Dietary Supplements: Formulated into two-piece hard capsules, compressed tablets, and dry powder stick-packs aimed at intracellular NAD+ restoration.
- Mitochondrial & Metabolic Support Formulas: Integrated into sports nutrition complexes and metabolic health blends targeting cellular energy production and endurance recovery.
- Topical Skin Barrier Repair Creams: Incorporated into anhydrous or low-water emulsions to boost epidermal cellular repair, reduce oxidative photo-damage, and improve skin tone elasticity.
- Functional Beverage & Nutraceutical Premixes: Used in dry-blend sachet matrices engineered for rapid aqueous dissolution prior to consumption.
Technical Data Sheet (TDS) & Processing Parameters
| Parameter | Specification Standard | Testing Method |
|---|---|---|
| Chemical Name / INCI | Nicotinamide Riboside Chloride / Nicotinamide Riboside Cl | IUPAC Identification |
| CAS Number | 23111-00-4 | Chemical Registry Index |
| Appearance | White to Off-White Crystalline Powder | Visual Inspection |
| Assay (Purity) | ≥ 98.0% (Free Nicotinamide ≤ 1.0%) | RP-HPLC |
| Molecular Weight (MW) | 290.70 Da | Mass Spectrometry (MS) |
| Heavy Metals (Total) | ≤ 10 ppm (Pb ≤ 2ppm, As ≤ 1ppm, Cd ≤ 1ppm, Hg ≤ 0.1ppm) | ICP-MS |
| Residual Solvents | Acetone ≤ 500 ppm; Methanol ≤ 100 ppm; Ethanol ≤ 1000 ppm | GC-Headspace |
| Microbiological Limits | Total Plate Count ≤ 1,000 cfu/g; Yeast & Mold ≤ 100 cfu/g; E. coli Negative | USP <61/62> / AOAC |
| Commercial Packaging | 1kg/Vacuum Aluminum Foil Bag; 25kg/Fiber Drum with Double PE Liners | Export Sealed Standard Packaging |
| Shelf Life | 24 Months Stored at 2°C–8°C Sealed and Protected from Moisture/Light | Real-Time Stability Testing |
Formulation & Processing Directives
- Recommended Dosage: 100 mg to 300 mg daily for oral dietary supplements; 0.5% to 2.0% w/w in topical cosmetic skin care preparations.
- Thermal Stability Profile: Thermal exposure during processing must remain strictly under 45°C. Prolonged heating triggers glycosidic bond cleavage, producing free nicotinamide and reducing active potency.
- Optimal pH Stability Range: Aqueous formulations maintain structural integrity best between pH 3.5 and pH 5.5. Alkaline environments above pH 6.8 accelerate hydrolytic degradation.
- Processing Environment: Humidity-controlled packaging environments maintained at relative humidity below 40% RH prevent deliquescence and lump formation during blending.
Global Logistics & Matrix Distribution
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Air Freight (DHL/FedEx/UPS) | Ideal for <50 kg | Higher Cost Per Kg | Door-to-door expedited courier dispatch taking 2 to 3 business days. Packaged in sealed foil barrier bags containing active desiccant packs to prevent ambient humidity exposure. |
| Standard Air Cargo | Optimal for >50 kg | Moderate Cost | Airport-to-airport transit within 3 to 5 business days. Balanced delivery timeline for urgent commercial manufacturing cycles with full temperature monitoring options. |
| Ocean Freight (FCL/LCL Container) | Preferred for >500 kg | Highly Economical | Seaport-to-seaport bulk freight taking 5 to 7 days for regional routes. Shipped inside sealed moisture-proof pallets with desiccant protection for large-scale production orders. |
Technical Capabilities & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, expanding robust bio-synthesis and chemical crystallization platforms with a broad portfolio covering thousands of plant extract ingredients and premium anti-aging active compounds. Continuous crystallization control yields tight particle size distribution curves, eliminating batch-to-batch dissolving variances during large-scale liquid or solid processing runs.
Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts.
Quality Management: In-house testing facility combined with independent third-party verification to ensure consistent batch compliance.
Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support.
Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation.
Frequently Asked Questions
What is the minimum order quantity (MOQ) for Nicotinamide Riboside Chloride?
Commercial MOQ starts at 1 kg sealed inside a protective vacuum foil bag. R&D evaluation samples ranging from 100 g to 1 kg are dispatched upon customer request.
What lead times apply to commercial scale bulk orders?
Active warehouse stock between 1,000 kg and 2,000 kg dispatches within 3 to 5 business days. Production runs require 10 to 14 business days from formal purchase order approval.
How does NutraJagen ensure material stability against ambient moisture?
Packaging occurs in cleanroom environments with RH below 40%. Products are sealed in double PE inner liners encased in heavy-duty aluminum foil barrier bags containing active desiccant pouches.
Which analytical quality documents are issued with each commercial shipment?
Every shipment is accompanied by a batch-specific COA featuring HPLC assay profiles, free nicotinamide impurity limits, GC residual solvent analysis, ICP-MS heavy metals, and complete MSDS documentation.
Can NutraJagen support custom particle sizes or specialized OEM blends?
Yes, custom particle size milling, specialized dry premixes, and private-label packaging configurations are available under contract manufacturing agreements.
Request Bulk Quotation & Technical Documentation
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