Astragalus Extract Astragaloside IV
NutraJagen Astragalus Extract is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Astragalus Membranaceus Root Extract | Off-White to Brown Yellow Powder | Astragaloside IV 0.3%-1%, Cycloastragenol 50%-98%, Polysaccharides 20%-30%.
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Astragalus Extract (HPLC Astragaloside IV / Cycloastragenol & UV Polysaccharides)
HPLC: Astragaloside IV 0.3%-1% | Cycloastragenol 50%-98% | UV: Polysaccharides 20%-30%
Polysaccharides: Water Soluble | Cycloastragenol: Ethanol & DMSO Soluble
784.97 (Astragaloside IV) / 490.72 (Cycloastragenol) | Astragalus membranaceus Root
Nutraceutical, Pharmaceutical & Cosmetic Grade
ISO22000, HACCP, HALAL Certified
Astragalus Extract (HPLC Astragaloside IV 0.3%-1%, Cycloastragenol 50%-98%, UV Polysaccharides 20%-30%) is a standardized botanical complex derived from the dried roots of Astragalus membranaceus (CAS: 84687-43-4). Commercial extraction often yields variable molecular fractions, leading to batch inconsistency and severe formulation turbidities in liquid matrices. Multi-stage counter-current extraction combined with macroporous resin purification isolates distinct active moieties: water-soluble polysaccharides, bioavailable triterpenoid saponins, and ultra-pure aglycone derivatives verified via HPLC-ELSD and UV-Vis spectroscopy. High-purity Cycloastragenol up to 98% appears as a crystalline off-white powder, while water-dispersible polysaccharides supply dense immunomodulatory carbohydrates for oral delivery. Formulators integrate these distinct grades into anti-aging topical emulsions, targeted longevity capsules, and immune-support wellness sachets. Bulk buyers obtain fully traceable phytochemical profiles, zero solvent residues, and solid analytical repeatability across all scale manufacturing runs.
Core Health/Functional Benefits & Commercial Applications
Core Health & Functional Benefits: Triterpenoid saponins and heteropolysaccharides operate through distinct biochemical cascades within human biological systems. Cycloastragenol serves as a potent small-molecule activator of the enzyme telomerase ($hTERT$). Telomerase activity reverses progressive telomere attrition in senescent T-lymphocytes, restoring cellular longevity and mitotic capacity. Simultaneously, Astragaloside IV downregulates nuclear factor kappa B ($NF-\kappa B$) signaling, attenuating inflammatory cytokine expression ($TNF-\alpha$, $IL-6$) while suppressing matrix metalloproteinase-1 ($MMP-1$) synthesis to preserve extracellular matrix structural integrity. High-molecular-weight polysaccharides bind directly to toll-like receptor 4 ($TLR4$) on macrophage surfaces. Macrophage activation drives phagocytic activity, boosting endogenous interferon-gamma ($IFN-\gamma$) production to bolster systemic innate immunity. Furthermore, saponin fractions enhance myocardial sodium-potassium ATPase ($Na^+/K^+-ATPase$) activity, supporting cardiac contractility and vascular microcirculation.
Targeted Industry Applications:
- Cellular Longevity & Anti-Aging Supplements: Encapsulated 90%–98% Cycloastragenol targeted at 5mg–20mg daily for telomere maintenance and cellular rejuvenation formulations.
- Immune Support Dietary Formulas: High-density 30% Polysaccharide powders combined with zinc and vitamin C in drink sachets or hard gelatin capsules.
- Topical Skin Barrier & Rejuvenation Serums: Liposomal Astragaloside IV (0.5%–1.0%) formulated into premium facial creams to suppress photoaging and accelerate dermal wound recovery.
- Cardiovascular Health Capsules: Standardized Astragaloside IV integrated with Coenzyme Q10 for endothelial integrity and microvascular support.
- Nutriceutical Adaptogen Powders: Water-dispersible 20% Polysaccharides blended into functional green superfood drinks for metabolic stamina.
Technical Specifications (TDS)
| Parameter Item | Testing Standard Specification | Test Method |
|---|---|---|
| Botanical Source / INCI | Astragalus membranaceus Root Extract | Microscopic & Thin-Layer Chromatography |
| CAS Registry Number | 84687-43-4 (Astragaloside IV) / 78574-94-4 (Cycloastragenol) | CAS Index Chemical Identification |
| Physical Appearance | Brownish Yellow (Polysaccharides) to White Fine Powder (98% Cycloastragenol) | Visual Sensory Inspection |
| Active Marker Assay | Astragaloside IV 0.3%-1% | Cycloastragenol 50%-98% | Polysaccharides 20%-30% | HPLC-ELSD (Saponins) / UV-Vis (Polysaccharides) |
| Particle Size Distribution | 100% passing through 80 Mesh (Custom micronization available) | USP <786> Particle Size Analysis |
| Loss on Drying & Total Ash | Loss on Drying ≤5.0% | Total Ash ≤5.0% | Gravimetric Analysis (USP <731> / <561>) |
| Heavy Metals Control | Pb ≤2.0ppm, As ≤1.0ppm, Cd ≤1.0ppm, Hg ≤0.1ppm | ICP-MS (Inductively Coupled Plasma) |
| Residual Solvent Control | Ethanol ≤5,000ppm | Methanol & Ethyl Acetate Non-Detectable | Headspace GC-MS |
| Microbiological Limits | TPC ≤1,000 CFU/g, Yeast & Mold ≤100 CFU/g, Salmonella/E. coli Negative | USP <2021/2022> Microbiological Examination |
| Commercial Packaging | 1kg aluminum vacuum bags / 25kg fibre drums with interior food-grade PE bags | Export Industrial Grade Standard |
| Shelf Life & Storage | 24 Months stored in tightly sealed containers protected from ambient light (<20°C) | Stability Testing Protocol |
Formulation & Processing Guidelines
- Recommended Active Dosages: Cycloastragenol 98%: 5mg–20mg/day; Astragaloside IV 1%: 50mg–100mg/day; Polysaccharides 30%: 250mg–1000mg/day. Cosmetic topical usage ranges between 0.1% and 0.5% weight volume.
- Processing Heat Tolerance: Triterpenoid aglycones maintain chemical stability up to 90°C for brief thermal processing under 20 minutes. Polysaccharides exhibit superior heat resistance up to 100°C in liquid formulations.
- Solubility & pH Parameters: Polysaccharides dissolve smoothly in warm aqueous phases (pH 4.5–7.5). Crystalline Cycloastragenol requires initial solubilization in ethanol, propanediol, or oil phases before emulsification.
- Phase Addition Protocol: Introduce Cycloastragenol during the cool-down phase (<45°C) in cosmetic emulsions to preserve surfactant-lipid micro-structures.
Logistics & Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express (<50kg) | R&D Samples & High-Value Extracts | Door to Door | 2-3 Days | Dispatched via DHL/FedEx. High-security tracking, ideal for high-purity Cycloastragenol shipments requiring rapid customs processing. |
| Air Freight (>50kg) | Commercial Batch Orders | Airport to Airport | 3-5 Days | Optimal speed-to-cost ratio for commercial polysaccharide lots. Controlled atmosphere eliminates ambient humidity risks. |
| Sea Freight (>500kg) | Bulk Industrial Tonnage | Seaport to Seaport | 5-7 Days (Regional) / 15-25 Days (Global) | Lowest freight cost for heavy polysaccharide volume. Palletized drums receive specialized desiccants against marine moisture fluctuations. |
Technical & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients engineered for international compliance.
Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts. Raw Astragalus membranaceus roots undergo GAP-compliant farming verification, excluding synthetic growth enhancers.
Quality Management: In-house testing facility combined with independent third-party verification to ensure consistent batch compliance. HPLC-ELSD and ICP-MS hardware validate every production drum before release, preventing batch variation.
Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support. Ph.D. analytical chemists guide clients through saponin dissolution and liposomal dispersion techniques.
Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation. Standardized commercial packets feature full Certificates of Analysis, MSDS, non-GMO statements, and regulatory dossier support.
Frequently Asked Questions (B2B Commercial)
What are the MOQ terms across different Astragalus Extract active specifications?
Standard Astragalus Polysaccharides and 1% Astragaloside IV start at 1 Kilogram. High-purity Cycloastragenol (90% and 98%) carries a flexible 100g minimum trial order for R&D evaluation.
What lead time can be expected for bulk commercial orders above 500kg?
Active spot inventory dispatches within 24 to 48 hours. Large customized production runs require 7 to 10 working days, inclusive of third-party analytical validation.
How is Cycloastragenol solubility maintained in topical cosmetic emulsions?
Cycloastragenol requires pre-dissolution in organic phases such as ethanol or propanediol before addition to oil-in-water systems. Our technical team provides precise co-solvent ratios.
Which quality and safety certifications accompany bulk shipments?
Every shipment contains batch-specific COAs, ISO22000, HACCP, and HALAL accreditations, alongside ICP-MS heavy metal, solvent residue, and microbiological safety reports.
Do you offer custom particle mesh sizes or carrier-free extract options?
Yes. We supply 100% pure carrier-free extracts for clean-label compliance and offer particle jet-milling down to 120 mesh for rapid capsule dissolution.
Request Direct Factory Quote & Technical Documentation
Access real-time inventory availability, request pilot sample packs, or consult our technical specialists regarding HPLC-verified Astragalus active specifications.
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