Dihydrohonokiol-B (DHH-B / CAS 343282-38-0) Powder 60% 98%
NutraJagen Dihydrohonokiol-B (DHH-B) is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Magnolia officinalis / Dihydrohonokiol-B | Off-White to Pale Yellow Powder | Standardized 60% & 98% (HPLC).
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Dihydrohonokiol-B (DHH-B) Powder 60% 98% Bulk Supply
60% & 98% (HPLC)
Lipophilic / Ethanol / Lipids
268.35 g/mol | Magnolia Bark
Nutraceutical & Cosmetic Grade
ISO22000, HACCP, HALAL
Dihydrohonokiol-B (DHH-B) represents a targeted hydrogenated derivative of honokiol, isolated and refined from Magnolia officinalis bark to achieve standardized 60% and high-purity 98% active assay thresholds (CAS: 343282-38-0). Traditional botanical extraction yields variable neolignan fractions. Industrial catalytic hydrogenation coupled with preparative chromatography solves this potency fluctuation, securing an exceptionally stable biphenyl molecular structure. High lipophilicity enables rapid cell membrane penetration, addressing the poor bioavailability profile common to native magnolia polyphenol crude powders. Formulators seamlessly incorporate this active into lipid-based dietary delivery systems, softgel oil matrices, and advanced lipid topical emulsions. Direct factory synthesis guarantees sub-ppm heavy metal profiles, strict residual solvent control under EP/USP limits, and complete lot-to-lot bio-equivalence for global brand owners.
Core Health/Functional Benefits & Commercial Applications
Core Functional Mechanisms: Dihydrohonokiol-B exhibits potent positive allosteric modulation at $GABA_A$ receptor subtypes, demonstrating significantly higher binding affinity compared to unhydrogenated honokiol parent molecules. Biochemical assays confirm its capacity to upregulate central inhibitory neurotransmission without triggering receptor desensitization. Beyond neuro-behavioral pathways, DHH-B potently inhibits nuclear factor kappa B ($NF-\kappa B$) activation, blocking downstream transcription of pro-inflammatory cytokines including $TNF-\alpha$, $IL-1\beta$, and $IL-6$. Hydroxyl radical scavenging kinetics show exceptional lipid peroxidation chain-breaking capability. In cutaneous applications, DHH-B downregulates matrix metalloproteinase-1 ($MMP-1$) expression caused by solar ultraviolet radiation, safeguarding dermal structural collagen networks.
Targeted Industry Applications:
- Advanced Stress & Neuro-Calming Capsules: Formulated as a primary active at 7.5mg–15mg per unit dose to support GABAergic balance and healthy cortisol responses.
- Liposomal Sleep Support Tinctures: Integrated into medium-chain triglyceride (MCT) oil or phospholipid carriers for accelerated systemic delivery.
- Dermo-Soothing & Anti-Aging Serums: Applied at 0.1%–0.5% concentrations in lipid phases to calm neurogenic inflammatory skin conditions and preserve elastin matrices.
- Post-Procedure Recovery Creams: Blended into anhydrous or thick lipid emulsions to suppress micro-vascular erythema and tissue oxidative stress following aesthetic procedures.
Technical Specifications (TDS)
| Parameter Item | Testing Standard Specification | Test Method |
|---|---|---|
| Botanical / INCI Name | Magnolia officinalis / Dihydrohonokiol-B | Taxonomic / INCI Standard |
| CAS Number | 343282-38-0 | CAS Index |
| Appearance | Off-white to pale yellow crystalline powder | Visual Inspection |
| Assay / Standardization | 60.0% Grade / 98.0% Ultra-Pure Grade | HPLC |
| Molecular Formula / MW | $C_{18}H_{20}O_2$ / 268.35 g/mol | Calculation |
| Melting Point Range | 84.0°C – 88.0°C | USP <741> |
| Heavy Metals (as Pb) | ≤ 10 ppm (Pb ≤2ppm, As ≤1ppm, Cd ≤1ppm, Hg ≤0.1ppm) | ICP-MS |
| Residual Solvents | Ethanol ≤5,000 ppm, Methanol ≤300 ppm, Hexane <290 ppm | GC-HS |
| Microbiological Limits | TPC ≤1,000 CFU/g, Yeast & Mold ≤100 CFU/g, Pathogens Negative | USP <2021/2022> |
| Commercial Packaging | 1kg aluminum foil bag / 25kg fiber drum with double inner PE bags | Industrial Standard |
| Shelf Life | 24 Months stored in sealed original container away from light (<25°C) | Stability Protocol |
Formulation & Processing Guidelines
- Recommended Dosage: Dietary supplements: 7.5mg to 15mg per daily serving; Topical cosmetic formulations: 0.05% to 0.5% active content weight ratio.
- Thermal Processing Tolerance: Stable up to 80°C in lipid phase systems for brief heating cycles; avoid open flame heating above 90°C.
- Optimal pH Stability: Solubilizes cleanly in hydrophobic solvents between pH 4.5 and 7.5; maintain formulation within neutral limits.
- Incorporation Phase: Dissolve fully into organic carrier oils, ethanol phase, or lipid base before emulsification or capsule filling operations.
Logistics & Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express (DHL/FedEx) | Small Cargo (<50kg) | Higher unit cost | Door-to-Door courier service. Transit time: 2–3 business days. Sealed thermal protection packing. |
| Air Freight | Medium Commercial (>50kg) | Moderate cost | Airport-to-Airport dispatch. Transit time: 3–5 business days. Rapid customs clearance support. |
| Sea Freight | Industrial Bulk (>500kg) | Optimal freight cost | Seaport-to-Seaport LCL/FCL. Transit time: 5–7 days regional, 15–25 days intercontinental. Palletized. |
Technical & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients engineered for global distribution.
Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts. Raw material extraction protocols utilize food-grade solvents, reducing environmental burden while safeguarding molecular active yields.
Quality Management: In-house testing facility combined with independent third-party verification to ensure consistent batch compliance. Dedicated high-performance liquid chromatography systems rigorously measure enantiomeric purity and eliminate trace impurites before dispatch.
Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support. Chemical engineers assist client formulation teams with solubility troubleshooting, oil-phase stability, and customized encapsulation challenges.
Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation. International regulatory dossiers, batch-specific COAs, and stability validation data remain accessible upon client demand.
Frequently Asked Questions (B2B Commercial)
What is the Minimum Order Quantity (MOQ) for DHH-B powder?
Commercial MOQ is set at 1 Kilogram packaged in sealed aluminum foil units. Laboratory sample kits (10g–50g) are available for verified corporate formulation labs upon request.
What is the typical lead time for industrial-scale bulk shipments?
Active spot stock orders dispatch within 2 business days. Large-scale custom production campaigns (100kg+) require 7 to 10 working days for processing and analytical testing release.
How does DHH-B maintain stability against oxidative degradation over time?
Catalytic hydrogenation of the allylic side chain substantially reduces susceptibility to photo-oxidation compared to crude honokiol. Storing below 25°C under nitrogen flushing ensures 24-month stability.
What compliance documentation is provided with bulk DHH-B orders?
Each shipment includes a full Certificate of Analysis (COA), Safety Data Sheet (MSDS), ISO22000/HACCP/HALAL certificates, BSE/TSE-Free declarations, and Heavy Metal/Solvent screening records.
Can NutraJagen supply custom oil premixes or liposomal solutions of DHH-B?
Yes. Our engineering facilities support custom oil-phase pre-dissolution, liposomal carrier encapsulation, and specialized micronization to match client formulation parameters.
Secure Direct Factory Pricing & Technical Documentation
Check active inventory status, request free laboratory pilot samples, or connect directly with our technical team for custom formulation assistance.
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