Palmitoyl Hexapeptide-14 (CAS 891498-01-4)
NutraJagen Palmitoyl Hexapeptide-14 is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Palmitoyl Hexapeptide-14 | Off-White to Light Yellow Powder | Assay ≥98.0% (HPLC).
📦 MOQ & Packaging: Min Order 0.01Kg | Standard 10g 100g 1Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 10Kg–20Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Palmitoyl Hexapeptide-14 (CAS 891498-01-4) Powder ≥98.0% Manufacturer
NutraJagen Palmitoyl Hexapeptide-14 is a bioengineered lipopeptide combining a bioactive short-chain peptide motif with an N-terminal palmitoyl fatty acid chain to yield an assay purity of ≥98.0% via precise solid-phase synthesis. Covalent lipid modification overcomes the native stratum corneum barrier. High-performance liquid chromatography ensures residual trifluoroacetic acid stays under 0.5% while controlling individual peptide impurities below 1.0%. Exceptional oil solubility and glycol compatibility eliminate emulsion instability risks during high-shear lipid phase operations. Formulators integrate this active into high-performance skin barrier restoration creams, matrix-rebuilding facial serums, and clinical-grade anti-aging treatments. Global cosmetic enterprises depend on this standardized raw material for reproducible batch-to-batch biological potency, superior thermal stability during emulsification, and reliable structural integrity across demanding commercial formulations.
Core Functional Mechanisms & Target Formulations
1. Core Health/Functional Benefits
Fibroblast Proliferation & Collagen Synthesis: Direct stimulation of dermal fibroblasts upregulates Type I and Type III collagen mRNA gene expression. Accelerated extracellular matrix deposition increases dermal density and restores skin structural integrity.
Inflammatory Mediator Downregulation: Suppresses matrix metalloproteinase production while modulating pro-inflammatory cytokine cascades. Attenuating enzymatic collagen degradation protects newly synthesized matrix proteins from premature breakdown.
Transdermal Permeation & Cellular Signaling: Attached palmitic acid lipophilic tail facilitates rapid lipid bilayer intercalation. Deep cutaneous penetration ensures target receptor interaction at lower active concentrations without causing cell toxicity.
2. Targeted Industry Applications
Matrix-Restoring Anti-Wrinkle Serums: Formulated into anhydrous or oil-in-water serums at 0.005%–0.05% active powder concentration to target deep nasolabial folds and structural sagging.
Clinical Skin Barrier Repair Creams: Incorporated into lipid-rich barrier restoration emulsions designed to speed up post-peel recovery and reconstruct compromised dermal tissue.
Periorbital Restorative Emulsions: Blended into firming eye creams to rebuild thinning sub-dermal connective layers and reduce micro-vascular sagging.
Nighttime Cellular Recovery Balm Outlines: Added to rich lipid balms for sustained nocturnal transdermal delivery during peak skin repair cycles.
Technical Data Sheet (TDS) & Operational Guidelines
| Parameter | Specification Standard | Test Method |
|---|---|---|
| INCI Name | Palmitoyl Hexapeptide-14 | Standard Nomenclature |
| CAS Number | 891498-01-4 | CAS Index |
| Appearance | Off-white to light yellow powder | Visual Inspection |
| Assay (Peptide Purity) | ≥98.0% (Single Impurity ≤ 1.0%) | HPLC |
| Molecular Weight (MW) | ~980.2 g/mol | MS / ESI |
| Heavy Metals Control | Total ≤ 10 ppm (Pb ≤ 2 ppm, As ≤ 1 ppm, Cd ≤ 1 ppm) | ICP-MS |
| Residual Solvents | Acetonitrile ≤ 410 ppm, Trifluoroacetic Acid ≤ 0.5% | GC-HS / HPLC |
| Microbiological Profile | Total Plate Count < 100 CFU/g; Pathogens Negative | USP / EP Standard |
| Commercial Packaging | 1kg/vacuum aluminum foil bag, 25kg/fiber drum with dual PE liners | Standard Export Packaging |
| Shelf Life | 24 Months stored in sealed containers protected from light at -15°C to 5°C | Stability Testing |
Formulation & Operational Guidelines
- Recommended Dosage: Pure active powder: 0.005%–0.05% (50 ppm to 500 ppm); Standard liquid masterbatch (0.1% solution): 1.0%–5.0% in final finished formulations.
- Thermal Processing Limits: Maintain temperature under 60°C during phase integration. Thermal degradation accelerates beyond 75°C. Predissolving in polar glycols allows direct addition to emulsions below 45°C.
- pH Stability Range: Optimal chemical stability occurs between pH 4.5 and 7.0. Extreme pH values below 3.5 or above 8.0 cause amide bond cleavage and palmitoyl chain cleavage.
- Phase Integration Strategy: Dissolve in oil phase, glycol vehicle, or ethoxydiglycol. Compatible with non-ionic emulsifiers, ceramides, squalane, and structural lipopeptides. Avoid strong oxidizing conditions.
Global B2B Supply Chain & Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Courier (DHL/FedEx/UPS) | < 50kg | Premium Speed, Higher Cost | Door to Door delivery; transit time 2-3 business days. Gel-pack temperature insulation protects peptide structural integrity during express transport. |
| Air Freight | > 50kg | Moderate Freight Cost | Airport to Airport delivery; transit time 3-5 business days. Rapid air transit suited for medium-scale manufacturing schedules. |
| Sea Cargo | > 500kg | Lowest Unit Freight Cost | Seaport to Seaport delivery; transit time 5-7 days (regional) or 15-30 days (global). Climate-controlled reefer containers maintain target temperatures during sea passage. |
Manufacturing Infrastructure & Corporate Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients, cosmetic neuropeptides, and bio-functional actives engineered for global personal care and health industries.
Natural Solutions: Focus on plant-based ingredients and clean-label bioactive peptide structures aligned with modern, sustainable international concepts.
Quality Management: In-house testing facility equipped with LC-MS, HPLC, and ICP-MS combined with independent third-party verification to ensure batch compliance.
Professional Team: Skilled commercial and technical teams offering proactive formulation guidance and responsive R&D support for complex cosmetic applications.
Customer Support: End-to-end service team maintaining close tracking from initial inquiry through order dispatch to ensure long-term commercial cooperation.
Frequently Asked Questions (Technical & B2B Sourcing)
What minimum order quantity (MOQ) applies to Palmitoyl Hexapeptide-14 bulk orders?
Initial research pilot evaluations begin at 0.01kg packaged in double-sealed aluminum foil pouches under argon padding. Commercial production runs scale into standard 1kg Bag containing dual food-grade polyethylene interior liners.
What dispatch lead time governs bulk orders exceeding 10kg?
Active factory stocks hold 10kg to 20kg ready for immediate dispatch within 48 hours following PO sign-off. Industrial batch synthesis for volumes above active inventory limits requires 7 to 10 business days.
How does Palmitoyl Hexapeptide-14 enhance transdermal cellular signaling?
N-terminal conjugation with lipophilic palmitic acid overcomes the stratum corneum barrier. Enhanced transdermal penetration allows direct interaction with dermal fibroblasts, signaling TGF-beta pathway activation and upregulation of Type I collagen genes.
Which quality documentations accompany each dispatched batch from NutraJagen?
Every shipment dispatches alongside batch-specific COA, SDS, ISO22000, HACCP, and HALAL documentation. Third-party testing records verifying HPLC purity, residual TFA content, heavy metals, and microbiological safety are supplied upon request.
Does NutraJagen provide liquid masterbatches for cold-process manufacturing?
Custom 1000 ppm liquid solutions dissolved in ethoxydiglycol, glycerin, or water-glycol complexes are supplied for seamless incorporation during low-temperature production phases.
Request Commercial Quote & Free Pilot Samples
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