Biotinoyl Tripeptide-1 (299157-54-3)
NutraJagen Biotinoyl Tripeptide-1 is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Biotinoyl Tripeptide-1 | White Lyophilized Powder | Purity ≥98.0% (HPLC).
📦 MOQ & Packaging: Min Order 10g | Standard 100g, 1Kg/Bottle or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO9001, HALAL, and Kosher to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 50Kg–120Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Biotinoyl Tripeptide-1
Biotinoyl Tripeptide-1 is a highly pure, synthetically produced peptide conjugate combining biotin (Vitamin H) with the biologically active tripeptide GHK (Glycyl-Histidyl-Lysine). This molecular coupling leverages the metabolic co-enzyme properties of biotin and the extracellular matrix-repairing capabilities of GHK to target hair follicle senescence directly. Solid-phase peptide synthesis pathways minimize free amine impurities, resulting in a stable, white lyophilized powder that easily dissolves in cold water without aggregating. High-affinity binding characteristics ensure targeted delivery to the hair bulb, where it stimulates cellular adhesion proteins and accelerates structural keratin synthesis. Our bulk cosmetic active offers cosmetic formulators an advanced, non-hormonal pathway to prevent hair shedding and stimulate growth, providing verified stability and exceptional raw material purity for competitive global brands.
Core Benefits & Commercial Applications
Core Hair Follicle Anchoring and Keratinocyte Stimulation: The chemical structure of Biotinoyl Tripeptide-1 promotes the synthesis of adhesion molecules, specifically Laminin 5 and Collagen IV, within the dermal papilla matrix. Increasing these anchoring proteins physically secures the hair shaft within the follicle, extending the anagen (growth) phase and delaying the telogen (shedding) transition. In-vitro research shows that this compound significantly increases keratinocyte proliferation at the hair bulb, improving hair diameter and structural strength. Mitigating the effects of dihydrotestosterone (DHT) protects follicle cells from premature atrophy, maintaining optimal follicular vascularization and nutrient delivery.
Targeted Industry Applications: Formulators integrate this dual-action peptide into professional-grade hair care and color cosmetics targeting sparse or thinning hair. It serves as the primary functional ingredient in clinical hair loss prevention serums, scalp-stimulating lotions, and leave-on scalp treatments. In color cosmetics, it is widely used in premium eyelash lengthening mascaras, brow-thickening gels, and lash conditioning primers. Its clean compatibility profile makes it ideal for inclusion in professional post-transplant scalp recovery sprays and daily beard-growth oils.
Technical Specifications & Formulation Guidelines
| Parameter | Specification Details |
|---|---|
| INCI Name | Biotinoyl Tripeptide-1 |
| CAS Number | 299157-54-3 |
| Chemical Formula | C24H38N8O6S |
| Appearance | White to off-white lyophilized powder |
| Purity (HPLC) | ≥98.0% |
| Molecular Weight (MW) | 567.0 g/mol |
| Heavy Metals | ≤10 ppm total (As ≤2 ppm, Pb ≤5 ppm) |
| Water Content (KF) | ≤5.0% |
| Microbial Limits | Total Plate Count ≤100 cfu/g, Yeast & Mold ≤10 cfu/g, Pathogens Negative |
| Commercial Packaging | 10g, 100g, 1Kg per high-barrier pharmaceutical-grade bottle |
| Shelf Life | 24 months when stored at 2-8°C in sealed original container |
Formulation Processing Parameters: Incorporating this active peptide requires specific processing conditions to maintain its structural integrity:
- Recommended Dosage: Pure powder: 0.005%–0.05% (w/w). Standardized 1% (1000 ppm) solution: 1.0%–5.0% (w/w).
- pH Stability Range: Broadly stable within pH 4.0 to 6.0, with optimal stability around pH 5.0 to 5.5 to prevent peptide hydrolysis.
- Thermal Tolerance: Sensitive to prolonged high temperatures. Must be added to the aqueous phase during the cooling phase, below 40°C.
- Solubility Profile: Highly soluble in water, glycerin, and glycols. Insoluble in lipids, oils, and non-polar organic solvents.
Global Logistics & Sea-Air Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express (DHL/FedEx/UPS) | Best for orders <50kg. Higher unit cost, highly cost-effective for sensitive active ingredients. | Door-to-door expedited delivery, customs clearance managed by carrier, typical transit 2-3 business days globally. |
| Air Freight | Suited for mid-volume batches (50kg to 500kg). Balanced cost structure with fast delivery. | Airport-to-airport transit. Local broker handles import customs, typical transit 3-5 business days. |
| Sea Freight | Suited for heavy bulk orders >500kg. Lowest overall transport cost per kilogram. | Port-to-port delivery. Full container (FCL) or less-than-container (LCL) options, transit times vary between 15-30 days based on port. |
Technical & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, with a broad portfolio covering thousands of plant extract ingredients and advanced biosynthetic cosmetic peptides. Our global footprint is built on four core operational pillars:
- Natural Solutions: Focus on plant-based and biomimetic ingredients aligned with clean, sustainable, and health-oriented international concepts, meeting strict eco-responsibility benchmarks.
- Quality Management: In-house testing facility combined with independent third-party verification to ensure consistent, traceable batch-to-batch chemical compliance and structural identity.
- Professional Team: Skilled commercial and technical teams providing proactive regulatory guidance, custom solution development, and highly responsive R&D support.
- Customer Support: End-to-end service team maintaining close follow-up from initial inquiry to final port delivery, establishing frictionless post-sale technical support.
Technical FAQ
What is the minimum commercial order volume (MOQ) for this active peptide powder?
Our factory standards permit a minimum commercial packaging volume starting at 10 grams. We provide trial units of this size to facilitate pilot formulation and compatibility testing before committing to large-scale bulk procurement.
What is the typical commercial lead time for dispatching an international air cargo order?
Standard stock orders under 5Kg are processed, packed, and dispatched within 48 hours of payment verification. For large custom synthesized quantities or bulk solutions, our production cycle spans 7 to 10 working days.
What stability data supports the transport and storage of Biotinoyl Tripeptide-1?
Our peptide powder remains stable for up to 24 months when kept at 2-8°C in a dry environment. For brief international transit, its robust chemical structure easily tolerates ambient room-temperature conditions without measurable degradation.
Does your manufacturing conform to international cosmetic compliance structures?
Yes, our production operates under verified ISO9001 quality management systems. Our material complies with global cosmetic requirements, including the EU, US, and China’s IECIC lists. We provide full regulatory dossiers upon request.
Do you support the manufacturing of pre-dissolved liquid solutions for this peptide?
Yes, we supply customized liquid concentrations (typically 1000 ppm or 5000 ppm) dissolved in high-purity water, glycerin, or butylene glycol matrices. This service offers commercial clients a direct-to-emulsion fluid step during production.
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