Pentapeptide-18 (CAS 64963-01-5)
NutraJagen Pentapeptide-18 is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Pentapeptide-18 | White Crystalline Powder | Assay ≥98.0% (HPLC).
📦 MOQ & Packaging: Min Order 0.01Kg | Standard 10g 100g 1Kg/Bag or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 10Kg–20Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Pentapeptide-18 (CAS 64963-01-5) Powder ≥98.0% Manufacturer
NutraJagen Pentapeptide-18 is a synthetic biomimetic neuropeptide consisting of five amino acids (Tyr-D-Ala-Gly-Phe-Leu) engineered via advanced solid-phase peptide synthesis to achieve a minimum assay purity of ≥98.0%. Structural stability challenges frequently compromise expression-line attenuation peptides during large-scale industrial compounding. Controlled liquid-chromatographic purification ensures individual synthesis impurities remain strictly below 0.5% while eliminating harmful coupling reagents and heavy metal residues. Formulators incorporate this active into high-tier anti-aging emulsions, targeted periocular gels, and medical-grade anti-wrinkle serums where precise neuromuscular relaxation is desired. Premium cosmetic manufacturers secure undeniable batch consistency, rapid cold-water dissolution, and verified long-term stability needed to support premium brand positioning globally.
Core Functional Mechanisms & Target Formulations
1. Core Health/Functional Benefits
Enkephalin-Biomimetic Neuromuscular Modulation: Binds specifically to enkephalin receptors on cutaneous nerve terminals. Activating G-protein coupled cascades triggers hyperpolarization of the neuronal membrane, effectively dampening the electrical excitation that initiates muscle contraction.
Inhibition of Voltage-Gated Calcium Channels: Modulates voltage-dependent calcium channel influx into presynaptic neurons. Restricting intra-neuronal calcium ions prevents synaptic vesicle fusion, directly suppressing acetylcholine release across the neuromuscular junction.
Synergistic Expression Line Attenuation: Targets neuromuscular transmission along pathways distinct from SNARE-complex cleaving peptides. Combining Pentapeptide-18 with Acetyl Hexapeptide-8 delivers additive suppression of facial micro-contractions, accelerating the smoothing of forehead furrows and crow’s feet.
2. Targeted Industry Applications
Premium Anti-Aging & Expressive Line Serums: Formulated into concentrated aqueous serums at 0.005%–0.01% pure active (or 3%–10% of standard liquid premix) to target dynamic facial wrinkles around the forehead, glabella, and mouth.
Targeted Periocular Eye Creams & Hydrogels: Integrated into lightweight eye repair fluids to visibly smooth crow’s feet and fine expression lines without causing irritation around delicate orbital skin.
Medical Aesthetics Post-Procedure Maintenance: Blended into recovery creams and post-botulinum maintenance lotions to prolong the visible smooth skin benefits of clinical cosmetic injections.
Firming Neck & Decollete Emulsions: Added to intensive skin-firming lotions designed to smooth horizontal neck lines and crepey skin texture.
Technical Data Sheet (TDS) & Operational Guidelines
| Parameter | Specification Standard | Test Method |
|---|---|---|
| INCI Name | Pentapeptide-18 | Standard Nomenclature |
| CAS Number | 64963-01-5 | CAS Index |
| Appearance | White to off-white crystalline powder | Visual Inspection |
| Assay (Peptide Purity) | ≥98.0% (Single Impurity ≤ 0.5%) | HPLC |
| Molecular Weight (MW) | 569.65 g/mol | MS / ESI |
| Heavy Metals Control | Total ≤ 10 ppm (Pb ≤ 2 ppm, As ≤ 1 ppm, Cd ≤ 1 ppm) | ICP-MS |
| Residual Solvents | Acetonitrile ≤ 410 ppm, Trifluoroacetic Acid ≤ 0.5% | GC-HS / HPLC |
| Microbiological Profile | Total Plate Count < 100 CFU/g; Pathogens Negative | USP / EP Standard |
| Commercial Packaging | 1kg/vacuum aluminum foil bag, 25kg/fiber drum with dual PE liners | Standard Export Packaging |
| Shelf Life | 24 Months stored in sealed containers protected from light at 2°C–8°C | Stability Testing |
Formulation & Operational Guidelines
- Recommended Dosage: Pure active powder: 0.001%–0.01% (10 ppm to 100 ppm); Liquid premix solution (0.05% stock): 3.0%–10.0% in final finished formulations.
- Thermal Stability Parameters: Extended heat causes peptide backbone degradation. Sustained processing temperatures above 40°C should be avoided. Add during the final cooling phase under slow stirring.
- Optimal pH Range: Demonstrates high chemical stability between pH 4.5 and 7.0. Extreme acidic (pH < 3.5) or alkaline (pH > 8.0) environments hydrolyze peptide bonds.
- Phase & Compatibility Notes: Readily soluble in water and aqueous glycols. Fully compatible with hyaluronic acid, polyols, non-ionic emulsifiers, and biomimetic peptides such as Acetyl Hexapeptide-8. Avoid strong oxidizing systems or unchelated divalent metal ions.
Global B2B Supply Chain & Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Courier (DHL/FedEx/UPS) | < 50kg | Premium Speed, Higher Cost | Door to Door delivery; transit time 2-3 business days. Cold-pack insulated packaging preserves peptide structure against thermal degradation during express transit. |
| Air Freight | > 50kg | Moderate Freight Cost | Airport to Airport delivery; transit time 3-5 business days. Balanced air logistics solution providing rapid transit for mid-tier commercial volumes. |
| Sea Cargo | > 500kg | Lowest Unit Freight Cost | Seaport to Seaport delivery; transit time 5-7 days (regional) or 15-30 days (global). Climate-controlled reefer container options maintain batch integrity during ocean transport. |
Manufacturing Infrastructure & Corporate Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients, specialized biomimetic peptides, and high-purity cosmetic actives engineered for global personal care and health industries.
Natural Solutions: Focus on plant-based ingredients and bioactive peptide structures aligned with clean, sustainable, and health-oriented international concepts.
Quality Management: In-house testing facility utilizing LC-MS, HPLC, and ICP-MS combined with independent third-party verification to ensure consistent batch compliance.
Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support for complex peptide formulations.
Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless commercial cooperation.
Frequently Asked Questions (Technical & B2B Sourcing)
What minimum order quantity (MOQ) applies to Pentapeptide-18 bulk commercial shipments?
Initial evaluation pilot lots start at 0.01kg packaged in light-protected, vacuum-sealed aluminum foil bags. Standard commercial consignments ship in 1kg fiber drums fitted with dual food-grade polyethylene liners.
What dispatch timeline applies to commercial orders exceeding 10kg?
Warehouse reserves maintain 10kg to 20kg available for instant dispatch within 48 hours. Custom synthesis or specific physical solution processing above 10kg requires 7 to 10 working days.
How does the neuromuscular mechanism of Pentapeptide-18 complement Argireline in anti-wrinkle formulations?
Pentapeptide-18 mimics enkephalin signaling to close calcium channels and reduce neuronal excitability. Coupling this mechanism with Argireline SNARE-complex destabilization yields demonstrated synergistic reduction in expression wrinkle depth.
Which quality compliance documents accompany each batch delivered from the plant?
Every batch dispatches with an official Certificate of Analysis (COA), MSDS, ISO22000, HACCP, and HALAL documentation. Independent third-party lab records verifying heavy metals, residual solvents, and HPLC purity are available on request.
Can NutraJagen supply pre-dissolved liquid masterbatches or custom concentration dilutions?
NutraJagen offers liquid premixes (such as 0.05% aqueous or glycerin solutions) and customized carrier systems tailored to specific client manufacturing requirements.
Request Commercial Quote & Free Pilot Samples
Access direct factory volume pricing, download complete technical dossiers, and request pilot testing samples for your anti-wrinkle or dermal formulation projects.
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