Palmitoyl Pentapeptide-4 (CAS 214047-00-4)
NutraJagen Palmitoyl Pentapeptide-4 is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Palmitoyl Pentapeptide-4 | White to Off-White Crystalline Powder | Assay ≥98.0% (HPLC).
📦 MOQ & Packaging: Min Order 0.01Kg | Standard 10g 100g 1Kg/Bag or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 10Kg–20Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Palmitoyl Pentapeptide-4 (CAS 214047-00-4) Powder ≥98.0% Manufacturer
NutraJagen Palmitoyl Pentapeptide-4 is a bio-engineered matrikine-mimetic signal peptide (Pal-Lys-Thr-Thr-Lys-Ser) produced via solid-phase peptide synthesis to guarantee an assay purity of ≥98.0%. Native peptide fragments exhibit low skin permeability due to the hydrophobic stratum corneum barrier. Conjugating a sixteen-carbon palmitoyl chain boosts lipophilicity, driving cellular uptake into deeper dermal layers while maintaining structural stability against enzymatic cleavage. Controlled chromatographic purification restricts single synthesis impurities below 0.5% and removes residual trifluoroacetic acid. Formulators incorporate this active ingredient into restorative anti-wrinkle creams, firming night serums, and intensive eye contour gels requiring proven extracellular matrix renewal. International cosmetics brands secure batch-to-batch consistency, high thermal stability, and verified bio-activity needed to drive premium anti-aging product lines.
Core Functional Mechanisms & Target Formulations
1. Core Health/Functional Benefits
Fibroblast Activation & Extracellular Matrix Synthesis: Acts as a specific matrikine messenger that binds membrane receptors on dermal fibroblasts. Activating intracellular signaling cascades upregulates the gene expression of collagen Type I, collagen Type IV, fibronectin, and hyaluronic acid.
Dermal Architecture Restoration: Rebuilds damaged structural proteins within the dermal matrix. Quantitative assays show significant collagen synthesis upregulation, thickening the dermis and smoothing established wrinkle depth.
Enhanced Lipophilic Permeation Profile: Palmitic acid conjugation elevates skin absorption kinetics up to 100-fold relative to un-alkylated Lys-Thr-Thr-Lys-Ser pentapeptides. Rapid trans-epidermal diffusion ensures targeted action at the dermal-epidermal junction.
2. Targeted Industry Applications
High-Performance Anti-Aging Creams: Formulated into rich lipid-phase emulsions at 0.0005%–0.005% pure active powder (or 3%–5% of standard 100 ppm liquid solution) to repair deep facial furrows and restore skin density.
Targeted Periocular Eye Repair Gels: Integrated into delicate eye gels to rebuild fragile dermal collagen networks and reduce crow’s feet lines without triggering ocular irritation.
Post-Procedure Barrier Reconstruction Serums: Blended into medical-grade post-treatment serums to accelerate collagen remodeling after micro-needling, chemical peels, or fractional laser treatments.
Neck and Decollete Firming Emulsions: Incorporated into specialized body care lotions engineered to tighten slack skin and smooth horizontal neck creases.
Technical Data Sheet (TDS) & Operational Guidelines
| Parameter | Specification Standard | Test Method |
|---|---|---|
| INCI Name | Palmitoyl Pentapeptide-4 | Standard Nomenclature |
| CAS Number | 214047-00-4 | CAS Index |
| Appearance | White to off-white crystalline powder | Visual Inspection |
| Assay (Peptide Purity) | ≥98.0% (Single Impurity ≤ 0.5%) | HPLC |
| Molecular Weight (MW) | 802.05 g/mol | MS / ESI |
| Heavy Metals Control | Total ≤ 10 ppm (Pb ≤ 2 ppm, As ≤ 1 ppm, Cd ≤ 1 ppm) | ICP-MS |
| Residual Solvents | Acetonitrile ≤ 410 ppm, Trifluoroacetic Acid ≤ 0.5% | GC-HS / HPLC |
| Microbiological Profile | Total Plate Count < 100 CFU/g; Pathogens Negative | USP / EP Standard |
| Commercial Packaging | 1kg/vacuum aluminum foil bag, 25kg/fiber drum with dual PE liners | Standard Export Packaging |
| Shelf Life | 24 Months stored in sealed containers protected from light at 2°C–8°C | Stability Testing |
Formulation & Operational Guidelines
- Recommended Dosage: Pure active powder: 0.0005%–0.005% (5 ppm to 50 ppm); Liquid solution (100 ppm stock): 2.0%–5.0% in final finished formulations.
- Thermal Stability Parameters: Prolonged high temperatures cause lipophilic chain cleavage or peptide breakdown. Processing temperatures must be controlled below 40°C. Incorporate during the post-emulsification cooling step under gentle mixing.
- Optimal pH Range: Demonstrates high chemical stability between pH 5.0 and 7.0. Strong acidic (pH < 4.0) or alkaline (pH > 8.0) environments cause hydrolysis of peptide linkage sites.
- Phase & Compatibility Notes: Dissolves in glycols, polyols, and water when pre-dispersed with suitable solubilizers. Fully compatible with hyaluronic acid, niacinamide, non-ionic emulsifiers, and other signal peptides. Avoid strong oxidizing systems or unchelated heavy metal ions.
Global B2B Supply Chain & Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Courier (DHL/FedEx/UPS) | < 50kg | Premium Speed, Higher Cost | Door to Door delivery; transit time 2-3 business days. Cold-pack insulated packaging prevents peptide degradation during express air transport. |
| Air Freight | > 50kg | Moderate Freight Cost | Airport to Airport delivery; transit time 3-5 business days. Efficient air transport for mid-scale commercial production runs. |
| Sea Cargo | > 500kg | Lowest Unit Freight Cost | Seaport to Seaport delivery; transit time 5-7 days (regional) or 15-30 days (global). Temperature-controlled reefer containers maintain structural stability during ocean transit. |
Manufacturing Infrastructure & Corporate Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients, cosmetic neuropeptides, and bio-functional actives engineered for global personal care and health industries.
Natural Solutions: Focus on plant-based ingredients and clean-label bioactive peptide structures aligned with modern, sustainable international concepts.
Quality Management: In-house testing facility equipped with LC-MS, HPLC, and ICP-MS combined with independent third-party verification to ensure batch compliance.
Professional Team: Skilled commercial and technical teams offering proactive formulation guidance and responsive R&D support for complex cosmetic applications.
Customer Support: End-to-end service team maintaining close tracking from initial inquiry through order dispatch to ensure long-term commercial cooperation.
Frequently Asked Questions (Technical & B2B Sourcing)
What minimum order quantity (MOQ) applies to Palmitoyl Pentapeptide-4 bulk commercial shipments?
Pilot lot evaluations start at 0.01kg packaged in light-shielded, vacuum-sealed aluminum foil pouches. Standard commercial consignments ship in 1kg fiber drums equipped with dual polyethylene inner liners.
What dispatch lead time applies to commercial bulk orders exceeding 10kg?
Active warehouse inventory reserves maintain 10kg to 20kg ready for immediate dispatch within 48 hours. Custom synthesis batches or specialized solution processing above 10kg require 7 to 10 working days.
How does palmitoylation alter the lipophilicity and cutaneous penetration of Pentapeptide-4?
Attaching a C16 palmitoyl aliphatic chain elevates lipophilicity, overcoming hydrophilic stratum corneum transport barriers to increase dermal penetration rates by up to 100-fold compared to hydrophilic native peptides.
Which quality compliance documents accompany each batch delivered from the production facility?
Every shipment dispatches alongside an official Certificate of Analysis (COA), Safety Data Sheet (MSDS), ISO22000, HACCP, and HALAL certificates. Independent third-party lab documentation verifying HPLC purity, heavy metals, and residual solvents is furnished upon request.
Can NutraJagen supply pre-dissolved liquid masterbatches or custom concentration dilutions?
NutraJagen manufactures tailor-made liquid masterbatches, including standard 0.01% (100 ppm) or 0.05% aqueous, glycerin, or liposomal solution systems tailored to specific client manufacturing protocols.
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