N-Acetyl Carnosine (NAC / CAS 56353-15-2)
NutraJagen N-Acetyl Carnosine is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: N-Acetyl Carnosine | White Crystalline Powder | Assay ≥99.0% (HPLC).
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
N-Acetyl Carnosine (NAC / CAS 56353-15-2) Powder ≥99.0% Manufacturer
NutraJagen N-Acetyl Carnosine is a acetylated derivative of the natural imidazole dipeptide L-carnosine (beta-alanyl-L-histidine), synthesized via controlled bio-chemical acetylation to reach a purity specification assay of ≥99.0%. Standard L-carnosine breaks down rapidly under serum carnosinase activity. Acetylation protects the molecular structure from premature enzymatic cleavage, allowing sustained delivery across lipid membranes and aqueous ocular barriers. High-purity crystallization controls individual related substances below 0.2% while maintaining exceptional aqueous dissolution without thermal degradation. Formulators integrate this active into sterile eye drop solutions, advanced anti-glycation facial serums, and cellular longevity oral supplements. Protecting functional proteins against advanced glycation end-products (AGEs) guarantees reliable performance for anti-aging brands across international markets.
Core Functional Mechanisms & Target Formulations
1. Core Health/Functional Benefits
Enzymatic Resistance & Membrane Translocation: Acetylation at the N-terminal amino group prevents immediate enzymatic hydrolysis by human carnosinase in plasma and ocular fluids. Intact molecules cross lipid-rich corneal epithelia and cellular lipid bilayers effectively before deacetylating gradually into active carnosine inside target tissues.
Inhibition of Advanced Glycation End-Products (AGEs): Competes with amino groups on structural proteins to react with reducing sugars and reactive carbonyl species (RCS) like methylglyoxal. Suppressing cross-linking reactions protects corneal crystalline proteins and dermal collagen fibrils from irreversible structural hardening.
Transition Metal Chelation & Hydroxyl Radical Scavenging: Imidazole ring structures chelate free copper and iron ions directly, preventing Fenton-type reactions. Neutralizing singlet oxygen and lipid peroxides maintains membrane fluidity and cellular homeostasis under oxidative stress.
2. Targeted Industry Applications
Ophthalmic Comfort Solutions & Lubricating Eye Drops: Formulated into 1.0% ophthalmic solutions designed to reduce lens lipid peroxidation, support corneal clarity, and alleviate age-related ocular fatigue.
Advanced Anti-Glycation Facial Serums: Integrated into high-performance skin care creams, firming essences, and eye contour gels aimed at inhibiting collagen cross-linking and maintaining skin elasticity.
Nootropic & Cellular Longevity Supplements: Blended into dietary capsules and sublingual powders targeted at neuroprotective health, exercise recovery, and intracellular pH buffering.
Post-Dermatological Treatment Repair Formulas: Incorporated into soothing emulsions applied after laser resurfacing or chemical peels to reduce reactive oxidative stress in healing tissues.
Technical Data Sheet (TDS) & Operational Guidelines
| Parameter | Specification Standard | Test Method |
|---|---|---|
| INCI / Chemical Name | N-Acetyl Carnosine / N-Acetyl-beta-alanyl-L-histidine | Standard Nomenclature |
| CAS Number | 56353-15-2 | CAS Index |
| Appearance | White to off-white crystalline powder | Visual Inspection |
| Assay (Purity) | ≥99.0% (Single Impurity ≤ 0.2%) | HPLC |
| Molecular Weight (MW) | 268.27 g/mol | MS / Calculation |
| Heavy Metals Control | Total ≤ 10 ppm (Pb ≤ 2 ppm, As ≤ 1 ppm, Cd ≤ 1 ppm) | ICP-MS |
| Residual Solvents | Meets strict EP / USP limit requirements | GC-HS |
| Microbiological Profile | Total Plate Count < 100 CFU/g; Pathogens Negative | USP / EP Standard |
| Commercial Packaging | 1kg/vacuum aluminum foil bag, 25kg/fiber drum with double PE liners | Standard Export Packaging |
| Shelf Life | 24 Months stored in sealed containers in a cool, dry place away from light (2°C–8°C recommended) | Stability Testing |
Formulation & Operational Guidelines
- Recommended Dosage: Ophthalmic solutions require 1.0% (w/v); topical anti-aging cosmetics use 0.2%–1.5%; oral supplement capsules recommend 50mg–200mg per serving.
- Thermal Stability Parameters: Stable in aqueous media up to 60°C for short durations. Adding the compound below 40°C during the final cooling phase of emulsion manufacturing prevents potential thermal degradation.
- Optimal pH Range: Demonstrates maximal stability in buffer solutions between pH 6.0 and 7.5. Avoid strong acidic (pH < 4.0) or strong alkaline environments to prevent deacetyl hydrolysis.
- Phase & Compatibility Notes: Highly water-soluble. Dissolve directly in the aqueous phase before emulsification. Compatible with hyaluronic acid, glycerin, peptidic active complexes, and non-ionic surfectants.
Global B2B Supply Chain & Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Courier (DHL/FedEx/UPS) | < 50kg | Premium Speed, Higher Cost | Door to Door delivery; transit time 2-3 business days. Sealed foil packaging with cold-pack protection preserves high-purity dipeptide integrity during rapid air transit. |
| Air Freight | > 50kg | Moderate Freight Cost | Airport to Airport delivery; transit time 3-5 business days. Ideal balance of rapid transit and controlled freight costs for commercial production schedules. |
| Sea Cargo | > 500kg | Lowest Unit Freight Cost | Seaport to Seaport delivery; transit time 5-7 days (regional) or 15-30 days (global). Climate-controlled container options protect large volume raw material batches against ocean temperature swings. |
Manufacturing Infrastructure & Corporate Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients, specialized amino acids, and high-purity synthetic dipeptides designed for worldwide health and cosmetic industries.
Natural Solutions: Focus on bioactive dipeptides and plant-based actives aligned with clean, sustainable, and health-oriented international formulation concepts.
Quality Management: In-house analytical core equipped with HPLC, NMR, LC-MS, and ICP-MS combined with independent third-party testing to ensure lot-to-lot analytical consistency.
Professional Team: Experienced commercial and technical support specialists providing proactive formulation guidance, regulatory documentation, and rapid R&D problem-solving.
Customer Support: End-to-end service team maintaining rigorous follow-up from sample evaluation to final port delivery and long-term regulatory compliance.
Frequently Asked Questions (Technical & B2B Sourcing)
What minimum order quantity (MOQ) applies to N-Acetyl Carnosine bulk shipments?
Commercial evaluation lots start at 1kg packaged in a vacuum-sealed aluminum foil bag. Standard bulk consignments ship in 25kg fiber drums with double food-grade PE liners.
What dispatch timeline is expected for commercial lots exceeding 500kg?
Active warehouse reserve maintains 1,000kg to 2,000kg ready for immediate dispatch within 48 hours. Custom synthesis or specific physical micronization runs above 500kg require 7 to 10 working days.
How does acetylation improve the stability of N-Acetyl Carnosine compared to pure L-carnosine?
Endogenous carnosinase enzymes in aqueous biological fluids rapidly hydrolyze pure L-carnosine into histidine and beta-alanine. N-acetylation creates steric protection around the nitrogen terminal, resisting enzymatic degradation and allowing sustained intracellular release.
Which compliance documentation accompanies each commercial batch?
Every batch is dispatched with an official Certificate of Analysis (COA), MSDS, ISO22000, HACCP, and HALAL certificates. Third-party testing records for heavy metals, residual solvents, and microbiological purity are supplied upon request.
Can NutraJagen provide customized solution blending or sterile ophthalmic grade processing?
NutraJagen provides tailored mesh size milling, low-endotoxin batches, and custom packaging configurations based on detailed technical consultation.
Request Commercial Quote & Free Pilot Samples
Access direct factory volume pricing, download full regulatory technical dossiers, and request pilot testing samples for your ophthalmic or cosmetic product lines.
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