Heptapeptide-10 (CAS 1228833-28-4)
NutraJagen Heptapeptide-10 is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Heptapeptide-10 | White to Off-White Crystalline Powder | Assay ≥98.0% (HPLC).
📦 MOQ & Packaging: Min Order 0.01Kg | Standard 10g 100g 1Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 10Kg–20Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Heptapeptide-10 (CAS 1228833-28-4) Powder ≥98.0% Manufacturer
NutraJagen Heptapeptide-10 is a high-potency bioengineered peptide synthesized via automated solid-phase peptide protocols to consistently yield an assay purity of ≥98.0% by HPLC. Molecular target engineering downregulates inflammatory pathway signals, suppressing substance P-induced cutaneous neuro-sensitization and reducing vascular hyperactivity in compromised epidermal tissues. Preparative reverse-phase chromatography isolates the primary heptapeptide sequence, maintaining individual related impurities below 1.0% while eliminating residual trifluoroacetic acid (TFA) down to sub-threshold trace limits. Rapid water solubility and stable integration into aqueous phase systems eliminate phase-separation risks during cold-process cosmetic manufacturing. Formulation chemists incorporate this peptide into post-procedure recovery serums, sensitive skin rescue gels, anti-redness emulsions, and barrier repair lotions targeting environmental or mechanical skin distress. Global cosmetic brand manufacturers rely on this standardized raw material for repeatable batch-to-batch biological potency, zero odor interference, and exceptional thermodynamic stability across diverse emulsion architectures.
Core Functional Mechanisms & Target Formulations
1. Core Health/Functional Benefits
Neurogenic Inflammation Downregulation: Suppresses substance P binding to neurokinin-1 (NK1) receptors in keratinocytes. Reduced signal transduction inhibits downstream production of pro-inflammatory cytokines such as IL-6, IL-8, and TNF-alpha.
Cutaneous Vasodilation Suppression: Modulates localized microvascular reactivity, blunting sudden flushing and persistent erythema induced by thermal stress, chemical irritants, or UV overexposure.
Epidermal Barrier Recovery Acceleration: Promotes cellular repair cascades, restoring transepidermal water loss (TEWL) values toward baseline in compromised or abraded skin layers.
2. Targeted Industry Applications
Post-Procedure Recovery Treatments: Integrated at 0.005%–0.01% active powder concentration (or 2.0%–5.0% of a 500 ppm liquid stock) into medical-grade recovery gels to calm post-laser or post-peel inflammation.
Anti-Redness & Rosacea Care Serums: Formulated into light aqueous solutions designed to lessen chronic facial flushing, diffuse capillary visibility, and tingling sensations.
Intensive Skin Barrier Repair Creams: Combined with ceramides and ectoin in heavy moisture emulsions to rebuild compromised stratum corneum lipids in reactive skin profiles.
Somatic Soothing Eye Contour Fluids: Blended into delicate periocular fluids to relieve puffy, irritated lower eyelids and reduce stress-induced skin fatigue.
Technical Data Sheet (TDS) & Operational Guidelines
| Parameter | Specification Standard | Test Method |
|---|---|---|
| INCI Name | Heptapeptide-10 | Standard Nomenclature |
| CAS Number | 1228833-28-4 | CAS Index |
| Appearance | White to off-white crystalline powder | Visual Inspection |
| Assay (Peptide Purity) | ≥98.0% (Single Impurity ≤ 1.0%) | HPLC |
| Peptide Content | ≥80.0% (Net Peptide Weight) | Elemental Analysis |
| Heavy Metals Control | Total ≤ 10 ppm (Pb ≤ 2 ppm, As ≤ 1 ppm, Cd ≤ 1 ppm) | ICP-MS |
| Residual Solvents | Acetonitrile ≤ 410 ppm, Trifluoroacetic Acid ≤ 0.5% | GC-HS / HPLC |
| Microbiological Profile | Total Plate Count < 100 CFU/g; Pathogens Negative | USP / EP Standard |
| Commercial Packaging | 1kg/vacuum aluminum foil bag, 25kg/fiber drum with dual PE liners | Standard Export Packaging |
| Shelf Life | 24 Months stored in sealed containers protected from light at 2°C–8°C | Stability Testing |
Formulation & Operational Guidelines
- Recommended Dosage: Pure active powder: 0.005%–0.01% (50 ppm to 100 ppm); Standard liquid masterbatch (0.05% solution): 1.0%–5.0% in finished commercial formulations.
- Processing Temperature Range: High thermal conditions induce amide bond hydrolysis. Maintain processing temperatures below 40°C. Add peptide during final cooling phase post-emulsification.
- Optimal pH Range: Exhibits maximum structural stability between pH 5.0 and 7.5. Avoid extreme acidic environments below pH 4.0 or alkaline conditions above pH 8.0.
- Solubility & Phase Compatibility: Highly soluble in water and glycerin-based polyol mixtures. Compatible with non-ionic emulsifiers, beta-glucan, hyaluronic acid, and soothing botanical extracts. Avoid strong oxidizing agents and unchelated metal ions.
Global B2B Supply Chain & Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Courier (DHL/FedEx/UPS) | < 50kg | Premium Speed, Higher Cost | Door to Door delivery; transit time 2-3 business days. Thermal insulation packs preserve cold-chain requirements during transit. |
| Air Freight | > 50kg | Moderate Freight Cost | Airport to Airport delivery; transit time 3-5 business days. Balanced cost structure suited for medium-scale manufacturing schedules. |
| Sea Cargo | > 500kg | Lowest Unit Freight Cost | Seaport to Seaport delivery; transit time 5-7 days (regional) or 15-30 days (global). Temperature-monitored containers prevent thermal degradation during extended sea transit. |
Manufacturing Infrastructure & Corporate Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients, functional bio-actives, and cosmetic peptides tailored for global personal care and pharmaceutical industries.
Natural Solutions: Focus on plant-based ingredients and clean-label bioactive peptide structures aligned with modern, sustainable international concepts.
Quality Management: In-house testing facility equipped with LC-MS, HPLC, and ICP-MS combined with independent third-party verification to ensure batch compliance.
Professional Team: Skilled commercial and technical teams offering proactive formulation guidance and responsive R&D support for complex cosmetic applications.
Customer Support: End-to-end service team maintaining close tracking from initial inquiry through order dispatch to ensure long-term commercial cooperation.
Frequently Asked Questions (Technical & B2B Sourcing)
What minimum order quantity (MOQ) applies to Heptapeptide-10 bulk orders?
Pilot trial batches start at 0.01kg contained in double-bagged aluminum foil pouches under nitrogen flushing. Commercial manufacturing requirements shift into standard 1kg export-grade fiber drums engineered with food-grade inner liners.
What dispatch lead time governs industrial orders exceeding 10kg?
Factory inventory maintains 10kg to 20kg active stock ready for immediate dispatch within 48 hours. Tailored liquid stock masterbatches or specialized packaging orders require 7 to 10 business days for complete processing.
How does Heptapeptide-10 mitigate neurogenic skin inflammation?
Direct inhibition of substance P-induced pro-inflammatory cascades suppresses interleukin release (IL-6 and IL-8). Reduced C-fiber activation lowers cutaneous hyper-reactivity, mitigating localized erythema and itching sensations.
Which quality documentation accompanies each dispatched batch from NutraJagen?
Every batch dispatches with an official Certificate of Analysis (COA), Safety Data Sheet (MSDS), ISO22000, HACCP, and HALAL certifications. Third-party analytical validation for HPLC purity, TFA residues, and heavy metals is furnished upon request.
Does NutraJagen supply pre-dissolved liquid stock solutions alongside raw powder?
NutraJagen provides stabilized liquid stock solutions, such as standard 0.05% (500 ppm) or 0.1% (1,000 ppm) aqueous or glycolic masterbatches engineered for direct cold-process addition.
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