Astragalus Extract Cycloastragenol TA-65 CAS 78574-94-4
NutraJagen Cycloastragenol (Astragalus membranaceus Extract) is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Astragalus membranaceus / Cycloastragenol | Off-White to White Powder | Active HPLC 10%, 50%, 98%.
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Astragalus Extract Cycloastragenol (CAS 78574-94-4) Bulk Supply
Astragalus Extract Cycloastragenol (CAS 78574-94-4), also structurally recognized as TA-65 derivative or (3beta,6beta,16beta,20R,24S)-20,24-epoxy-9,19-cyclolanostane-3,6,16,25-tetrol, represents a high-value triterpenoid aglycone derived via enzymatic hydrolysis of Astragaloside IV from Astragalus membranaceus roots. Extraction physics demand rigorous chromatographic separation to isolate this hydrophobic sapogenin moiety. Standard botanical processing suffers from residual glycoside contamination and batch potency drops; NutraJagen enforces dual-column preparative HPLC purification steps yielding standardized 10%, 50%, and ultra-pure 98% crystalline fraction tiers. Solid-state stability assays prove this crystalline aglycone preserves structural conformation against thermal shear up to 80°C, solving phase-separation and precipitation risks in topical liposomal vehicles and lipophilic oral lipid suspension matrices. Formulators integrate this active into high-tier anti-senescence dietary capsules, sublingual drops, and specialized skin barrier restoration creams. Standardized batch analytics provide global beauty brands and longevity laboratories with verifiable potency metrics, eliminating supply chain risk while accelerating brand market entry.
Core Health & Commercial Applications
Core Health & Physiological Mechanisms: Cellular biology studies confirm Cycloastragenol functions as a potent small-molecule telomerase activator. Telomeres shorten progressively during somatic cell division, inducing replicative senescence and cellular dysfunction. Research establishes that this triterpenoid molecule transiently activates human telomerase reverse transcriptase (hTERT) gene expression. hTERT activation elongates critically short telomeres without inducing uncontrolled cell transformation. Fibroblast proliferation assays demonstrate increased DNA repair kinetics, suppressed reactive oxygen species (ROS) accumulation, enhanced keratinocyte migration, and restored collagen type I synthesis in damaged dermal layers.
Targeted Industry Applications: R&D formulators deploy various purities based on specific final product architectures. Primary commercial delivery formats include anti-aging dietary capsules (utilizing 10% or 50% powder grades), sublingual oil drops, cellular longevity serums (formulated with 98% micro-fine powder dissolved in glycol matrices), liposomal skin barrier repair creams, and post-procedural recovery lotions.
Technical Specifications (TDS)
| Parameter | Specification Standard | Test Method |
|---|---|---|
| INCI / Botanical Source | Cycloastragenol / Astragalus membranaceus Root | Taxonomic Verification |
| CAS Registry Number | 78574-94-4 | CAS Index |
| Appearance | Light Yellow (10%) to Pure White Crystalline Powder (98%) | Visual Inspection |
| Active Assay (Cycloastragenol) | 10.0%, 50.0%, 98.0% Standardized Tiers | HPLC-ELSD / HPLC-MS |
| Identification / Structural Index | Matches Reference Standard (C30H50O5, MW 490.72 g/mol) | 1H-NMR / FT-IR |
| Loss on Drying | ≤ 2.0% | USP <731> |
| Heavy Metals Control | Total ≤ 10 ppm (Pb ≤ 2.0 ppm, As ≤ 1.0 ppm, Cd ≤ 0.5 ppm, Hg ≤ 0.1 ppm) | ICP-MS |
| Residual Solvents Control | Ethanol ≤ 5,000 ppm, Methanol ≤ 3,000 ppm, Ethyl Acetate ≤ 5,000 ppm | GC-HS |
| Microbiological Profile | Total Plate Count < 1,000 cfu/g; Yeast & Mold < 100 cfu/g; Pathogens: Negative | USP <2021> / <2022> |
| Commercial Packaging | 1Kg Aluminum Foil Bag / 25Kg Fiber Drum with Dual PE Food-Grade Liners | Export Packaging Standard |
| Shelf Life | 24 Months stored in tight, light-resistant containers at 2–8°C | Stability Testing Protocol |
Formulation Processing Guidelines: Recommended dosing ranges from 5 mg to 50 mg daily for oral dietary supplements based on active percentage purity. Cosmetic topical preparations achieve optimal biological efficacy at 0.01% to 0.1% active concentration of the 98% grade. Maintain formula pH within a stable 5.0 to 7.5 range. Due to limited aqueous solubility, pre-dissolve high-grade powders in organic solvents, ethoxydiglycol, or specialized lipid carriers prior to aqueous emulsification. Introduce this ingredient during the cool-down phase below 45°C.
Global Bulk Logistics Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Courier (DHL/FedEx) | < 50 kg | Higher Unit Cost | Door to Door delivery; 2–3 Days transit; Premium tracking for high-value 98% purity samples and small production batches. |
| Air Freight Cargo | 50 kg – 500 kg | Moderate Freight Cost | Airport to Airport; 3–5 Days transit; Fast customs clearance for commercial 10% and 50% bulk extract orders. |
| Ocean Sea Freight (FCL/LCL) | > 500 kg | Lowest Unit Freight Cost | Seaport to Seaport; 5–7 Days regional / 15–25 Days international transit; Optimized for large-scale botanical ingredient distribution. |
Technical & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients to support global cosmetic, nutraceutical, and pharmaceutical brands.
1. Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts, utilizing raw Astragalus membranaceus sourced directly from audited botanical growing bases.
2. Quality Management: In-house testing facility combined with independent third-party verification ensures consistent batch compliance, executing HPLC-ELSD assay screening, heavy metal ICP-MS quantification, and microbial testing on every batch.
3. Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support, assisting formulation chemists with solubility challenges, emulsion design, and active stabilization protocols.
4. Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation, backed by complete regulatory files, COAs, MSDS, and technical regulatory documentation.
Technical & Commercial FAQ
What is the Minimum Order Quantity (MOQ) for high-purity 98% Cycloastragenol?
High-purity 98% grade carries a flexible MOQ of 100g for research laboratories and pilot formulation assessments. Commercial 10% and 50% extract grades carry a standard 1Kg MOQ in sealed aluminum foil bags.
What lead time applies to commercial production quantities?
Active warehouse stock ranges between 1,000Kg and 2,000Kg across standard specifications, permitting dispatch within 48 hours. Custom purification or micronization requests require 7 to 10 working days.
How can formulators overcome the hydrophobic solubility of 98% Cycloastragenol in water systems?
Cycloastragenol dissolves readily in organic solvents such as ethanol or DMSO. In cosmetic aqueous systems, pre-dissolve the powder in glycols or incorporate it into lipid liposomal carriers prior to final emulsion blending.
Which quality documentation accompanies each commercial order?
Every lot ships with a batch COA containing HPLC purity chromatograms, Heavy Metal ICP-MS data, Residual Solvent GC profiles, MSDS, and ISO22000/HALAL compliance certifications.
Does NutraJagen support customized particle sizes or pre-mixed liquid solutions?
Yes, physical micronization down to 200 mesh is available to improve dissolution rates. Specialized OEM liquid dilutions using cosmetic-grade glycol bases can be manufactured upon request.
Request Factory-Direct Quotation & Pilot Samples
Contact our technical sales team directly to receive tiered volume pricing, review batch HPLC analytical dossiers, and arrange immediate laboratory sample evaluation.
Inquire via Email
We would love to speak with you.
Feel free to reach out using the below details.