Calcium L-threonate (CAS 70753-61-6)
NutraJagen Calcium L-threonate is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Calcium L-threonate | White to Off-White Powder | Active Assay ≥98.0%.
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Calcium L-threonate (CAS 70753-61-6) Bulk Supply
Calcium L-threonate (CAS 70753-61-6) represents a highly bioavailable calcium salt derived from the metabolic condensation of L-ascorbic acid, chemically structured as calcium (2R,3S)-2,3,4-trihydroxybutanoate. Standard industrial calcium inorganic salts suffer from poor gut permeability and gastrointestinal precipitation; this specific chelated-like structure bypasses traditional vitamin D3-dependent active transport pathways by utilizing passive intestinal transcellular transport mechanisms. Industrial formulation trials prove that its superior water solubility eliminates sedimentation risks in liquid delivery systems while resisting oxidation under elevated processing temperatures up to 85°C. Designed specifically for advanced dietary supplements, functional effervescent tablets, and medical nutrition formulations, its high physical compatibility prevents cross-linking reactions when co-formulated with sensitive botanical extracts or complex multi-mineral complexes. Global nutraceutical brand owners leverage this direct factory ingredient to secure verifiable batch-to-batch consistency, eliminate supply chain volatility, and capture premium market positioning in skeletal and cartilage health segments.
Core Health & Commercial Applications
Core Health & Physiological Mechanisms: Bio-mineral pharmacokinetic trials confirm that L-threonic acid serves as a active biological metabolite capable of stimulating osteoblast activity directly while upregulating collagen type I mRNA expression. Calcium ion transport efficiency increases significantly via transcellular pathways, yielding absorption rates reported to exceed 95% in comparative human intestinal epithelial cell models. Research demonstrates that L-threonate metabolites enhance extracellular matrix deposition and chondrocyte proliferation, providing dual structural benefits for both bone mineral density and articular cartilage tissue matrix integrity without inducing nephrolithiasis or intestinal discomfort typical of inorganic carbonate carriers.
Targeted Industry Applications: Formulators integrate this high-purity compound across multiple high-growth product categories. Core delivery formats include dietary supplement hard gelatin and HPMC capsules, direct-compression bone-density tablets, functional effervescent powders, ready-to-drink (RTD) therapeutic beverages, liquid bone-health syrups, and post-menopausal orthopedic medical nutrition sachets.
Technical Specifications (TDS)
| Parameter | Specification Standard | Test Method |
|---|---|---|
| Chemical Name | Calcium L-threonate | In-House / Chemical Standard |
| CAS Registry Number | 70753-61-6 | CAS Index |
| Appearance | White to Off-White Crystalline Powder | Visual Inspection |
| Assay Purity (Dry Basis) | ≥ 98.0% | Titration / HPLC |
| Elemental Calcium Content | 12.5% – 13.5% | AAS / ICP-OES |
| Loss on Drying | ≤ 1.0% | 105°C, 3 Hours |
| Heavy Metals (as Pb) | ≤ 10 ppm (Pb ≤2ppm, As ≤1ppm, Cd ≤1ppm, Hg ≤0.1ppm) | ICP-MS |
| Residual Solvents | Meets USP / EP Limits (Ethanol ≤5000ppm) | GC-HS |
| Microbiological Profile | Total Plate Count <1,000 cfu/g; Yeast/Mold <100 cfu/g; E. coli / Salmonella: Negative | USP / AOAC Standards |
| Commercial Packaging | 25 Kg Net Weight Fiber Drum with Double PE Food-Grade Liners | Export Packaging Standard |
| Shelf Life | 24 Months when stored under sealed, cool, dry conditions | Real-time Stability Data |
Formulation Processing Guidelines: Recommended inclusion levels range between 500 mg to 2,000 mg per daily adult serving depending on elemental target requirements. Maintain processing system pH between 4.5 and 7.2 to guarantee long-term ionic stability. The active compound exhibits solid thermal stability during short-term thermal processing up to 85°C. For liquid formulations, introduce the powder directly during the early aqueous phase under high-shear mechanical agitation to accelerate dissolution kinetics.
Global Bulk Logistics Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Courier (FedEx/DHL) | < 50 kg | Higher Unit Cost | Door to Door delivery; 2–4 Business Days transit time; Ideal for samples and urgent pilot production batches. |
| Air Freight Cargo | 50 kg – 500 kg | Moderate Freight Cost | Airport to Airport destination; 3–5 Business Days transit time; Optimal balance between velocity and air transport economics. |
| Ocean Sea Freight (FCL/LCL) | > 500 kg | Lowest Unit Freight Cost | Seaport to Seaport; 15–30 Days transit depending on trade lane; Designed for large-scale commercial factory orders. |
Technical & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, leveraging a broad portfolio covering thousands of plant extract ingredients to service leading international healthcare brands and chemical distributors.
1. Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts, guaranteeing raw material traceability from origin to finalized extract.
2. Quality Management: In-house testing facility combined with independent third-party verification ensures consistent batch compliance, executing HPLC, ICP-MS, and GC-MS testing protocols on every lot before factory release.
3. Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support, assisting formulation architects with solubility, compatibility, and dosage optimization.
4. Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation, backed by full regulatory file preparation including COA, MSDS, and allergen statements.
Technical & Commercial FAQ
What is the Minimum Order Quantity (MOQ) for bulk purchases?
Standard commercial packaging is 25 Kg per drum. For pilot trial formulations and laboratory validation orders, we accommodate small sample orders starting at 1 Kg.
What lead time can buyers expect for large-scale production orders?
We maintain a permanent active inventory buffer of 1,000 Kg to 2,000 Kg for immediate dispatch within 48 hours. Production scale-up for volumes exceeding 5 Metric Tons requires a 10 to 14 business day manufacturing cycle.
How does Calcium L-threonate behave in high-water aqueous solutions?
The compound exhibits solid water solubility (approx. 27 g/L at 20°C), forming clear, colorless solutions without secondary turbidity or precipitation. It remains stable across broad pH ranges typical of liquid supplement manufacturing.
Which quality documentation accompanies shipment dispatches?
Every production lot is dispatched with a batch-specific COA, Safety Data Sheet (MSDS), Heavy Metal Analysis report, and ISO22000/HALAL compliance statements. Third-party testing reports (SGS/Eurofins) are accessible upon request.
Does NutraJagen support customized micronization or OEM packaging?
Yes, we supply custom particle sizing ranging from standard 80 mesh up to 200 mesh micronized powder to meet specific suspension or direct-compression tableting parameters, alongside tailored drum labeling and liner packaging.
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