Retatrutide (CAS 2381089-83-2)
NutraJagen Retatrutide (CAS 2381089-83-2) is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Retatrutide / CAS 2381089-83-2 | White to Off-White Lyophilized Powder | Purity ≥99.0% (HPLC).
📦 MOQ & Packaging: Min Order 0.01Kg | Standard 1Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 10Kg–20Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Retatrutide (CAS 2381089-83-2) ≥99.0% Triple Agonist Peptide
Product Introduction
Retatrutide (CAS 2381089-83-2) is a synthetically engineered 39-amino-acid peptide sequence incorporating a fatty acid diacid moiety that functions as a single-molecule triple agonist target across glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon (GCG) receptors. Industrial peptide procurement routinely encounters batch inconsistency driven by incomplete chain assembly or residual trifluoroacetic acid (TFA) salts. Multi-stage preparative RP-HPLC combined with continuous solid-phase peptide synthesis (SPPS) yields consistent purity exceeding 99.0% with total residual TFA constrained below 0.5%. Formulators integrate this high-purity active ingredient into advanced metabolic research models, multi-pathway weight management platforms, and stable subcutaneous delivery systems. Physical stability remains exceptionally robust across balanced aqueous pH environments. Providing certified batch-to-batch structural integrity equips global pharmaceutical formulators and brand developers with absolute analytical reliability, accelerated formulation development, and uncompromised scalability.
Core Functionality & Targeted Applications
Core Health & Biological Functionality:
Simultaneous activation of three distinct metabolic receptors establishes potent, multi-directional physiological regulation. Binding to GIP receptors enhances glucose-dependent insulin secretion while insulating adipocytes against dysfunctional lipolysis. Simultaneous stimulation of GLP-1 receptors suppresses central appetite signaling within the arcuate nucleus, delays gastric transit times, and reduces postprandial glycemic spikes. Crucially, glucagon receptor recruitment accelerates basal energy expenditure by stimulating hepatic lipid oxidation and thermogenesis without inducing hyperglycemia. Pharmacokinetic parameters demonstrate high plasma albumin binding affinity via the C20 fatty acid side chain, extending systemic elimination half-life to approximately 6 days in human models. Clinical kinetic models confirm significant reductions in intrahepatic fat content alongside improved systemic insulin sensitivity across peripheral skeletal tissues.
Targeted Industry Applications:
- Triple-Target Metabolic Research Formulations: Integrated into pre-clinical and translational models studying complex metabolic syndrome interventions.
- Advanced Weight Management Preparations: Formulated into multi-pathway therapeutic solutions designed for deep adipose tissue reduction and thermogenic optimization.
- Subcutaneous Injectable Liquid Delivery Systems: Incorporated into isotonic buffered aqueous vehicles engineered for sustained parenteral release profiles.
- Hepatic Steatosis & Energy Metabolism Assays: Applied as a reference compound in diagnostic platforms mapping non-alcoholic fatty liver disease (NAFLD) parameters and thermogenic signaling pathways.
Technical Data Sheet (TDS) & Processing Parameters
| Parameter | Specification Standard | Testing Method |
|---|---|---|
| Chemical Name / INCI | Retatrutide / GIP/GLP-1/GCG Triple Receptor Agonist Peptide | IUPAC Identification |
| CAS Number | 2381089-83-2 | Chemical Registry Index |
| Appearance | White to Off-White Lyophilized Powder | Visual Inspection |
| Assay (Chromatographic Purity) | ≥ 99.0% (Single Impurity ≤ 0.5%) | RP-HPLC |
| Molecular Weight (MW) | 4731.33 ± 1.0 Da | ESI-MS / LC-MS |
| Heavy Metals (Total) | ≤ 10 ppm (Pb ≤ 2ppm, As ≤ 1ppm, Cd ≤ 1ppm, Hg ≤ 0.1ppm) | ICP-MS |
| Residual Solvents & Counterions | Acetonitrile ≤ 410 ppm; Acetate ≤ 10.0%; TFA ≤ 0.5% | GC-Headspace / IC |
| Bacterial Endotoxins & Bioburden | Endotoxins < 5 EU/mg; Total Microbial Count ≤ 100 cfu/g | LAL Assay / USP <61> |
| Commercial Packaging | 100g/Aluminum Foil Bag; 1kg/Vacuum Sealed Container; 25kg/Drum | Export Sealed Standard Packaging |
| Shelf Life | 24 Months Stored at -20°C Desiccated in Original Unopened Container | Real-Time Stability Testing |
Formulation & Processing Directives
- Recommended Concentration: 1.0 mg/mL to 12 mg/mL within sterile isotonic buffer systems, tailored to targeted administration profiles.
- Thermal Stability Profile: Lyophilized powder resists ambient thermal variation up to 30°C for brief intervals. Reconstituted liquid phases undergo accelerated peptide degradation above 25°C, requiring constant refrigerated storage (2°C–8°C).
- Optimal pH Stability Window: Solubilization stability peaks between pH 7.0 and pH 7.8 in phosphate-buffered saline (PBS) or histidine-buffered solutions. Acidic environments below pH 4.8 precipitate peptide aggregation.
- Handling Protocol: Dissolve using sterile bacteriostatic water under aseptic conditions. High-shear mixing, intense vortexing, or ultrasonic agitation must be avoided to prevent mechanical peptide clipping.
Global Logistics & Matrix Distribution
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express Cold-Chain (DHL/FedEx) | Ideal for <50 kg | Higher Cost Per Kg | Door-to-door temperature-monitored transit within 2 to 3 business days. Packaged in insulated containers with gel refrigerant packs ensuring sub-4°C stability. |
| Temperature-Controlled Air Freight | Optimal for >50 kg | Moderate Cost | Airport-to-airport transit within 3 to 5 business days. Managed via active cold-storage airport holds supported by priority customs documentation clearance. |
| Refrigerated Sea Freight (Reefer Container) | Preferred for >500 kg | Highly Economical | Seaport-to-seaport delivery taking 5 to 7 days for regional oceanic routes. Continuous power monitoring maintains container internal climate at 2°C–8°C or -20°C. |
Technical Capabilities & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, expanding technical synthesis platforms with a broad portfolio covering thousands of plant extract ingredients and specialized bio-active peptides. Proprietary purification technology mitigates residual solvent carryover while standardizing optical purity, guaranteeing repeatable formulation behavior across commercial scale-ups.
Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts.
Quality Management: In-house testing facility combined with independent third-party verification to ensure consistent batch compliance.
Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support.
Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation.
Frequently Asked Questions
What is the minimum order quantity (MOQ) for Retatrutide bulk powder?
Commercial order volumes start at 0.01 kg sealed inside a climate-controlled aluminum foil bag. Pilot laboratory test batches (1 g to 10 g) are supplied upon technical request.
What lead times apply to commercial scale peptide shipments?
In-stock inventory volumes (10 kg–20 kg) dispatch within 3 to 5 business days. Contract synthesis production runs require 10 to 14 business days from PO confirmation.
How is temperature stability preserved during international transit?
Bulk powders are double-vacuum sealed in moisture-proof aluminum bags and dispatched inside temperature-controlled cold-chain containers equipped with active refrigerant gel packs.
Which analytical quality documentation accompanies each commercial lot?
Every shipment includes a comprehensive Certificate of Analysis (COA) specifying RP-HPLC purity profiles, LC-MS mass verification, endotoxin testing, TDS, and Safety Data Sheets (MSDS).
Can NutraJagen supply customized solution preparations or sterile vial filling?
Yes, custom buffer reconstitutions, targeted lyophilization parameters, and specialized vial packaging configurations are fully accessible through OEM contract manufacturing agreements.
Request Bulk Quotation & Technical Documentation
Access factory-direct volume pricing, batch COAs, and technical evaluation samples. Our technical sales team responds within 12 business hours.
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