Andrographis Paniculata Extract (CAS 5508-58-7) Andrographolide 98%
NutraJagen Andrographis Paniculata Extract Andrographolide 98% is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Andrographis paniculata (Burm.f.) Wall. ex Nees | White Fine Crystalline Powder | Andrographolide ≥98.0% (HPLC) (CAS: 5508-58-7).
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Andrographis Paniculata Extract Andrographolide 98% (CAS 5508-58-7)
Product Introduction
Andrographis Paniculata Extract Andrographolide 98% (CAS 5508-58-7) is a ultra-pure labdane diterpenoid lactone isolated directly from the aerial parts of Andrographis paniculata (Burm.f.) Wall. ex Nees using multi-stage preparative column chromatography. Industrial scaling demands strict physical consistency. Our specialized crystallization processes eliminate trace bitter diterpene impurities, yielding a refined white crystalline powder with precise molecular stability and negligible batch variation. Formulators integrate this standardized active into advanced immune-support oral preparations and topical skin-soothing systems due to its high crystalline purity, defined melting profile, and physical compatibility with organic solvent vehicles. Delivering verified chemical identity across every lot provides international dietary supplement and cosmetic brand owners with reliable formulation stability, simplified regulatory audits, and predictable active release profiles in high-performance product architectures.
Core Functionality & Targeted Applications
Core Health & Biological Functionality:
Andrographolide functions as a potent immunomodulatory agent that modulates nuclear factor kappa B (NF-κB) transcription factors, downregulating pro-inflammatory enzyme systems including cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Experimental assays document marked reduction in pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Biological mechanisms include upregulation of endogenous antioxidant enzymes via the Nrf2 signaling pathway, reducing intracellular reactive oxygen species (ROS). Cutaneous investigations confirm that topical administration blunts UV-induced erythema, limits keratinocyte apoptosis, and regulates sebum lipid composition. Systemic applications show targeted cellular signaling support, hepatoprotective enzyme activity, and modulation of upper respiratory mucosal defense barriers.
Targeted Industry Applications:
- Advanced Respiratory & Immune Capsules: Processed with solid carriers into targeted dietary supplements designed to support seasonal upper respiratory tract health.
- Clinical Epidermal Soothing Serums: Formulated into anhydrous or glycolic cosmetic solutions targeting compromised skin barrier conditions and acute inflammatory redness.
- Hepatoprotective & Metabolic Formulations: Combined with lipotropic compounds in standardized oral tablets aimed at supporting hepatic detoxification enzymes.
- Purifying Scalp & Acne Care Treatments: Integrated into clarifying dermatological gels and lotions to balance microbial flora and reduce localized follicular inflammation.
Technical Data Sheet (TDS) & Processing Parameters
| Parameter | Specification Standard | Testing Method |
|---|---|---|
| Botanical Source / INCI | Andrographis paniculata Aerial Parts / Andrographolide | Botanical Identification / TLC |
| CAS Number | 5508-58-7 | Chemical Registry |
| Appearance | White Fine Crystalline Powder | Visual Inspection |
| Assay (Purity) | ≥ 98.0% Andrographolide | HPLC |
| Melting Point Range | 228.0°C – 232.0°C | Capillary Melting Point Method |
| Heavy Metals (Total) | ≤ 10 ppm (Pb ≤ 2ppm, As ≤ 1ppm, Cd ≤ 1ppm, Hg ≤ 0.1ppm) | ICP-MS |
| Residual Solvents | Meets EP/USP Limits (Ethanol ≤ 5000 ppm, Methanol ≤ 3000 ppm) | GC-Headspace |
| Microbiological Control | Total Plate Count ≤ 1000 cfu/g; Molds/Yeasts ≤ 100 cfu/g; Pathogens Negative | USP / Ph. Eur. |
| Commercial Packaging | 1kg/Aluminum Foil Bag; 25kg/Double-Lined Sealed Fiber Drum | Export Standard |
| Shelf Life | 24 Months in Original Unopened Drums Under Cool, Dark Storage | Real-Time Stability Testing |
Formulation & Processing Directives
- Recommended Dosage: 0.1% to 0.5% in topical skin preparations; 50mg to 200mg per unit dose in solid oral nutraceutical formulations according to target regional regulatory frameworks.
- Thermal Processing Stability: Stable up to 70°C for short emulsion phases. Prolonged heating above 80°C induces lactone ring hydrolysis.
- pH Stability Range: Optimal chemical integrity observed between pH 4.0 and pH 6.5. Alkaline conditions above pH 7.5 accelerate ester cleavage.
- Incorporation Protocol: Predissolve crystalline active in warm ethanol, propylene glycol, or DMSO before introduction into the primary oil/solvent phase.
Global Logistics & Matrix Distribution
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express (DHL/FedEx/UPS) | Ideal for <50 kg | Higher Cost Per Kg | Door-to-door transit within 2 to 3 business days. Full temperature monitoring for analytical validation samples and urgent pilot lots. |
| Air Freight | Optimal for >50 kg | Moderate Cost | Airport-to-airport transit within 3 to 5 business days. Rapid customs clearance with full export compliance paperwork. |
| Sea Freight (FCL/LCL) | Preferred for >500 kg | Highly Economical | Seaport-to-seaport delivery taking 5 to 7 days for regional oceanic routes (15-30 days internationally). Climate-controlled palletized containerization. |
Technical Capabilities & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, maintaining an extensive operations framework with a broad portfolio covering thousands of plant extract ingredients. Commercial extraction pipelines utilize specialized crystallization technologies that solve common industrial bottlenecks, ensuring stable lot-to-lot purity profiles for international manufacturing partners.
Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts.
Quality Management: In-house testing facility combined with independent third-party verification to ensure consistent batch compliance.
Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support.
Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation.
Frequently Asked Questions
What is the minimum order quantity (MOQ) for commercial orders?
Our baseline MOQ is 1 kg packaged in a double-sealed aluminum foil bag. Pilot laboratory validation samples ranging from 20g to 50g are supplied upon request for qualified buyers.
What lead times apply to commercial bulk purchases?
Standard orders ship from our active warehouse inventory (1,000kg–2,000kg) within 3 to 5 business days. Contract manufacturing runs require approximately 10 to 14 business days from order confirmation.
How is chemical stability maintained during international ocean transit?
Andrographolide crystalline powder is vacuum-sealed in moisture-barrier aluminum liners with desiccant packs, placed inside fiber drums. Shipments utilize temperature-monitored, desiccated containerization to prevent hydrolytic lactone cleavage.
What analytical documentation accompanies commercial deliveries?
Every commercial shipment includes a comprehensive Certificate of Analysis (COA) containing HPLC purity assays, GC residual solvent testing, ICP-MS heavy metal profiles, microbiological counts, TDS, and Safety Data Sheets (MSDS).
Can NutraJagen supply custom mesh sizes or liquid premix preparations?
Yes, our processing plant offers custom micronization down to 80-120 mesh and tailored liquid dispersions in glycolic or ethanol matrices based on client formulation requirements.
Request Bulk Pricing & Technical Documentation
Get direct factory pricing, batch COA, and free laboratory evaluation samples. Our technical sales team responds within 12 business hours.
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