Ashwagandha Extract (CAS 90131-43-4)
NutraJagen Ashwagandha Extract 10:1 2.5% 5% 10% Withanolides is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: Withania Somnifera Root Extract | Fine Brown Yellow Powder | Ratio 10:1 or HPLC Withanolides 2.5%, 5%, 10%.
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Ashwagandha Extract (10:1, HPLC Withanolides 2.5%, 5%, 10%)
10:1 Extract Ratio | HPLC Withanolides 2.5%, 5%, 10%
Water Dispersible & Hydro-alcoholic Soluble
Plant Extract / Withania somnifera Dried Roots
Nutraceutical, Pharmaceutical & Cosmetic Grade
ISO22000, HACCP, HALAL Certified
Ashwagandha Extract 10:1 2.5% 5% 10% Withanolides is a standardized botanical active extracted exclusively from the dried roots of Withania somnifera (CAS: 90131-43-4). Traditional botanical sourcing frequently suffers from inconsistent marker concentrations and high heavy metal loads that ruin downstream tablet compression. Hydro-alcoholic low-temperature extraction technology paired with membrane filtration yields uniform steroidal lactones, strictly eliminating cytotoxic Withaferin A excesses while maintaining total withanolide profiles at 2.5%, 5%, or 10% measured via High-Performance Liquid Chromatography. Formulation engineers easily integrate this free-flowing, fine brown powder into hard gelatin capsules, direct-compression dietary tablets, or functional RTD beverage premixes. Industrial clients secure batch-to-batch chemical uniformity, reduced sensory bitterness, and certified regulatory compliance for high-end adaptogenic product lines.
Core Health/Functional Benefits & Commercial Applications
Core Health & Functional Benefits: Bioactive withanolides—specifically Withanolide A, Withanolide B, and Withanoside IV—act directly upon the central nervous system to attenuate hypothalamic-pituitary-adrenal (HPA) axis hyperactivation. Physiological stress triggers excessive systemic release of glucocorticoids. Standardized withanolides downregulate adrenal cortisol production, significantly lowering serum stress biomarkers. At the neurochemical junction, steroidal lactones mimic gamma-aminobutyric acid ($GABA$) activity, binding to $GABA_A$ receptors to exert neuroprotective and anti-anxiety responses without motor sedation. High-potency extracts accelerate superoxide dismutase ($SOD$) and catalase ($CAT$) enzymatic synthesis in cerebral tissues, reducing lipid peroxidation. In skeletal muscle cells, withanolides stimulate mitochondrial biogenesis through peroxisome proliferator-activated receptor gamma coactivator 1-alpha ($PGC-1\alpha$) activation, boosting physical endurance and cardiorespiratory $VO_2$ max performance.
Targeted Industry Applications:
- Dietary Supplement Capsules: Formulated at 300mg–600mg per dose using 5% or 10% HPLC grades for stress reduction and cortisol management.
- Nootropic & Focus Tablets: Blended with L-theanine and phosphatidylserine to enhance executive cognitive performance and working memory.
- Functional Adaptogenic Beverages: Utilizing water-soluble 10:1 or 2.5% specifications in wellness shots and relaxation RTD drinks.
- Sports Nutrition Powders: Integrated into pre-workout or post-exercise recovery formulas to enhance muscle repair and cardiorespiratory endurance.
- Anti-Stress Skin Creams: Incorporated at 0.1%–0.5% in barrier repair lotions to combat cortisol-induced skin aging and cutaneous inflammation.
Technical Specifications (TDS)
| Parameter Item | Testing Standard Specification | Test Method |
|---|---|---|
| Botanical Source / INCI | Withania somnifera Root Extract | Microscopic & TLC Authentication |
| CAS Number | 90131-43-4 | CAS Index Registry |
| Appearance & Mesh Size | Fine Yellowish-Brown Powder | 100% through 80 Mesh | Visual & Sieve Analysis |
| Active Assay / Specification | 10:1 Ratio | Withanolides 2.5%, 5.0%, 10.0% | TLC (Ratio) / HPLC (Withanolides) |
| Withaferin A Limit | Controlled ≤0.5% (Non-cytotoxic compliance) | HPLC-UV |
| Loss on Drying & Ash | Loss on Drying ≤5.0% | Total Ash ≤5.0% | Gravimetric Method (USP <731>) |
| Heavy Metals (as Pb) | Pb ≤2.0ppm, As ≤1.0ppm, Cd ≤1.0ppm, Hg ≤0.1ppm | ICP-MS |
| Residual Solvents | Ethanol ≤5,000ppm | Methanol/Benzene Absent | HS-GC-MS |
| Microbiological Control | TPC ≤1,000 CFU/g, Yeast & Mold ≤100 CFU/g, E. coli Negative | USP <2021/2022> |
| Commercial Packaging | 1kg aluminum foil bags / 25kg paper drums with double food-grade PE liners | Industrial Packaging Standard |
| Shelf Life | 24 Months stored in cool, dark, dry conditions (<25°C, RH <60%) | Real-time & Accelerated Stability |
Formulation & Processing Guidelines
- Recommended Daily Dosage: 10:1 Ratio: 500mg–1000mg; 2.5% Withanolides: 300mg–600mg; 5% Withanolides: 250mg–500mg; 10% Withanolides: 100mg–250mg.
- Processing Heat Stability: Steroidal lactones remain structurally intact up to 80°C for short pasteurization cycles (under 15 minutes). Prolonged exposure above 90°C degrades active lactone rings.
- Optimal pH Range: Highly stable in aqueous solution between pH 3.5 and 7.2. Excessive alkalinity induces lactone ring hydrolysis.
- Incorporation Phase: Add during dry blending for capsules and tablets. In beverage applications, pre-dissolve in warm water (40°C–50°C) before high-shear blending.
Logistics & Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express (<50kg) | Small R&D Samples & Pilot Lots | Door to Door | 2-3 Days | Dispatched via DHL/FedEx/TNT. Real-time tracking, immediate customs clearance support, low payload friction. |
| Air Freight (>50kg) | Medium Commercial Orders | Airport to Airport | 3-5 Days | Optimal cost-to-speed balance. Temperature-controlled cargo holds prevent moisture absorption during transit. |
| Sea Freight (>500kg) | Bulk Container Dispatches | Seaport to Seaport | 5-7 Days (Regional) / 15-25 Days (Global) | Lowest unit logistics cost. Full pallet wrapping with desiccant protection against maritime moisture fluctuations. |
Technical & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients engineered for international compliance.
Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts. Sourcing strictly unadulterated Withania somnifera roots ensures zero synthetic marker spiking across all botanical batches.
Quality Management: In-house testing facility combined with independent third-party verification to ensure consistent batch compliance. High-Performance Liquid Chromatography (HPLC) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) screen every production lot prior to dispatch.
Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support. Application specialists assist client formulators in overcoming solubility and sensory bitterness challenges in functional food bases.
Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation. Standardized documentation packages include full Certificates of Analysis, safety data sheets, allergen declarations, and non-GMO statements.
Frequently Asked Questions (B2B Commercial)
What is the Minimum Order Quantity (MOQ) for standardized Ashwagandha Extract?
Standard commercial MOQ starts at 1 Kilogram packaged in vacuum-sealed foil bags. Complimentary 20g–50g laboratory sample packages are available for qualified R&D facilities.
What is the typical commercial lead time for 500kg+ bulk orders?
Active spot inventory dispatches within 24 to 48 hours. Large-scale contract manufacturing runs above 500 Kilograms require 7 to 10 working days, including complete internal analytical testing.
How is withanolide thermal stability preserved during high-temperature tableting or pasteurization?
Our low-temperature extraction preserves native steroidal structures. Short-duration pasteurization up to 80°C or direct tableting compression forces do not degrade active HPLC withanolide contents.
Which global compliance certifications accompany bulk Ashwagandha shipments?
All shipments include batch-specific COAs, ISO22000, HACCP, and HALAL certificates, alongside heavy metal ICP-MS, pesticide residue, and solvent testing documentation.
Do you offer customized mesh sizes or water-soluble liquid solutions for beverages?
Yes. We accommodate custom micronization up to 120 mesh for direct compression or supply fully water-soluble 10:1 extract formats optimized for liquid RTD formulations.
Request Direct Factory Quote & Technical Documentation
Access real-time inventory levels, request free laboratory pilot samples, or consult our application engineers regarding HPLC-certified withanolide specifications.
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