Tetrapeptide-21 (CAS 960608-17-7)
NutraJagen Tetrapeptide-21 is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: INCI: Tetrapeptide-21 | White to Off-White Synthetic Powder | Purity (HPLC) ≥98.0%.
📦 MOQ & Packaging: Min Order 0.01Kg | Standard 10 100 1Kg/Bag or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 10Kg–200Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
Tetrapeptide-21 (CAS 960608-17-7)
Tetrapeptide-21 is a highly focused synthetic signaling peptide (GEKG sequence) produced via controlled solid-phase synthesis to mimic native extracellular matrix breakdown fragments that upregulate collagen and hyaluronic acid expression in human dermal fibroblasts. High-pressure liquid chromatography purification protocols isolate the target peptide sequence to achieve a baseline purity of ≥98.0%, effectively capping individual peptide-related impurities below 0.8% and preventing raw material discoloration or unwanted cross-reactions during hot-process emusification. This short-chain amino acid complex dissolves rapidly in aqueous phases, retaining chemical stability across varying pH environments and demonstrating high compatibility with common anti-aging thickeners, non-ionic emulsifiers, and lipid carriers. Designed for inclusion in premium dermatological serums, targeted wrinkle-smoothing creams, and post-procedure barrier restoration treatments, it delivers reproducible biological efficacy, reliable batch-to-batch consistency, and complete compliance documentation required for international cosmetic safety dossiers.
Core Benefits & Commercial Applications
Extracellular Matrix Upregulation: Specific amino acid binding activates dermal fibroblast receptors without inducing inflammatory cascades. Collagen I, fibronectin, and hyaluronic acid gene transcriptions display substantial increases following localized application. Structural density within the dermal-epidermal junction recovers, leading to visible reduction in wrinkle depth and surface roughness.
Tissue Regeneration & Elasticity Enhancement: Dermal architectural remodeling speeds up while skin elasticity parameters show quantifiable improvements. Fibroblast proliferation rates rise, supporting faster cellular repair in stressed or photo-damaged cutaneous tissues. Viscoelastic recovery rates increase, reinforcing skin tightness against mechanical gravity deformation.
Targeted Industry Applications:
- Premium Anti-Aging Serums: Concentrated facial drop treatments targeting deep expression lines, periocular wrinkles, and loss of firmness.
- Skin Barrier Repair Creams: Rich nourishing emollient formulations designed for post-dermatological procedure recovery or compromised cutaneous barriers.
- Restructuring Neck & Decollete Lotions: Specialized body firming emulsions targeted at improving skin elasticity and micro-relief smoothing.
- Revitalizing Eye Contour Gels: Lightweight hydrogels focused on tightening delicate periorbital tissue and mitigating fine line depth.
Technical Specifications & Formulation Guidelines
| Parameter | Specification Standard | Test Method |
|---|---|---|
| INCI Name | Tetrapeptide-21 | Regulatory Standard |
| CAS Number | 960608-17-7 | CAS Registry |
| Appearance | White to Off-White Powder | Visual Inspection |
| Chemical Purity | ≥ 98.0% | HPLC Analysis |
| Peptide Content | ≥ 80.0% | Elemental Nitrogen |
| Molecular Weight (MW) | 426.47 g/mol ± 1.0 | Mass Spectrometry (MS) |
| Heavy Metals | Total ≤ 10 ppm (Pb ≤ 3ppm, As ≤ 2ppm) | ICP-MS |
| Residual Solvents | Meets USP/EP Limits (Acetonitrile ≤ 410ppm) | GC-Headspace |
| Microbial Count | Total Aerobic Plate Count < 100 CFU/g | USP <61> |
| Commercial Packaging | 100g/Aluminum Foil Bag, 1Kg/Bottle, 25Kg/Drum | Standard Export Pack |
| Shelf Life | 24 Months at -20°C; 12 Months at 2°C–8°C | Stability Testing |
Formulation Guidelines
Recommended Use Level: Powder form: 0.001%–0.005% (10 ppm to 50 ppm active concentration). Pre-dispersed liquid stock solution (500 ppm base): 0.5%–5.0% total formulation weight.
Processing & Heat Stability: Temperatures exceeding 40°C risk thermal degradation of short peptide chains. Pre-dissolve in aqueous phase and introduce during the post-emulsification cool-down step under gentle stirring.
pH & System Compatibility: Stable within a pH window of 4.0 to 7.0. Incompatible with strong oxidizing active systems, concentrated alpha-hydroxy acids (below pH 3.5), or heavy electrolyte loads that trigger protein complexation.
Logistics & Dispatch Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express (FedEx/DHL/UPS) | Volume < 50 Kg Higher unit cost, optimal for urgent pilot samples. |
Door to Door delivery; Transit time: 2-3 business days; Full cold-chain insulated packaging with frozen gel packs for temperature-sensitive peptides. |
| Air Freight | Volume > 50 Kg Balanced freight rate for medium commercial volumes. |
Airport to Airport service; Transit time: 3-5 business days; Full customs declaration assistance and regulatory document matching at destination airports. |
| Sea Freight | Volume > 500 Kg Lowest freight cost per kilogram for massive scale orders. |
Seaport to Seaport; Transit time: 5-7 days (Regional Asia) or 15-25 days (EU/Americas); Temperature-controlled reefer container solutions provided for industrial stock. |
Technical & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, maintaining a commanding position in active biochemical synthesis with a broad portfolio covering thousands of plant extract ingredients and specialized cosmetic peptides.
1. Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts. Raw material sourcing protocols enforce strict environmental audits to eliminate harmful residual chemicals, toxic solvents, or synthetic impurities.
2. Quality Management: In-house testing facility combined with independent third-party verification to ensure consistent batch compliance. Analytical platforms including HPLC, LC-MS, GC, and ICP-MS verify every purity parameter prior to customer release.
3. Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support. Cosmetic chemists and technical specialists assist clients in solving complex solubilization, carrier stability, and scale-up manufacturing challenges.
4. Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation. Buffer stock management strategies safeguard clients against global supply chain disruptions.
Frequently Asked Questions
Request Bulk Pricing & Technical Documentation
Connect directly with our technical sales managers for tier-volume discount quotes, batch COAs, and free lab sample requests.
Inquire via Email
We would love to speak with you.
Feel free to reach out using the below details.