N-Acetylneuraminic Acid (Sialic Acid) CAS 131-48-6
NutraJagen N-Acetylneuraminic Acid (Sialic Acid) is a premium ingredient factory-supplied directly for high-standard global formulation requirements.
🧪 Technical Specs: INCI: N-Acetylneuraminic Acid | Off-White to White Crystalline Powder | Purity: ≥98.0% (HPLC).
📦 MOQ & Packaging: Min Order 1Kg | Standard 25Kg/Drum or Tailored Custom Packaging.
🌍 Global Compliance: Certified by ISO22000, HACCP, and HALAL to meet stringent international audits.
⚡ Supply Capacity: Factory-direct stable bulk supply. Active Stocks: 1,000Kg–2,000Kg available for immediate dispatch. Full COA/MSDS ready.
*Storage Notice: Store in tightly closed original container, protected from light. Free laboratory pilot samples available.
N-Acetylneuraminic Acid (Sialic Acid) Powder ≥98.0% Bulk Supply
≥98.0% (HPLC Assay)
Water Soluble (50 mg/mL)
309.27 g/mol | Fermentation
Cosmetic & Food Grade
ISO22000, HACCP, HALAL
N-Acetylneuraminic Acid, commonly identified as Sialic Acid (CAS: 131-48-6), represents the predominant naturally occurring terminal monosaccharide attached to cell membrane glycans and glycolipids. Industrial-grade synthesis via precision bio-fermentation yields a crystalline powder standard exceeding 98.0% purity, mitigating trace endotoxin profiles and organic solvent residues. Complete aqueous solubility guarantees effortless cold-process integration without secondary heating steps, addressing a primary pain point in modern thermal-sensitive cosmetic emulsification and dietary powder blending. Formulation chemists leverage this high-purity monosaccharide across premium anti-aging topicals, cognitive support dietary matrices, and clinical infant nutrition systems requiring high physiological bio-compatibility. Direct factory synthesis ensures lot-to-lot bio-equivalence, delivering reproducible raw material behavior that protects complex manufacturing operations from batch variance.
Core Health/Functional Benefits & Commercial Applications
Core Functional Mechanisms: Cellular receptor interaction dynamics rely heavily on membrane terminal Sialic Acid residues. Biologically, N-Acetylneuraminic Acid modulates intercellular signaling pathways, suppresses inflammatory cytokine cascades, and enhances ganglioside biosynthesis within neural structures. In dermatological applications, topically applied Sialic Acid accelerates extracellular matrix recovery, mitigates matrix metalloproteinase production, and enhances epidermal moisture retention by reinforcing glycosaminoglycan networks. Clinical data demonstrates its capacity to protect neural cell membranes against oxidative degradation while supporting synaptic density in cognitive health applications.
Targeted Industry Applications:
- Premium Anti-Aging Serums & Ampoules: Applied at 0.5%–2.0% for cellular barrier repair and collagen matrix defense.
- Infant & Maternal Nutrition Blends: Integrated into powder bases to replicate essential functional oligosaccharide profiles found in human milk.
- Nootropic & Cognitive Health Capsules: Combined with phosphatidylserine and neuro-nutrients for memory support formulations.
- Skin Barrier Repair Creams: Formulated in lipid-replenishing emulsions targeting compromised stratum corneum integrity.
Technical Specifications (TDS)
| Parameter Item | Testing Standard Specification | Test Method |
|---|---|---|
| INCI Name | N-Acetylneuraminic Acid | Regulatory Standard |
| CAS Number | 131-48-6 | CAS Index |
| Appearance | Off-white to white crystalline powder | Visual Inspection |
| Purity / Active Content | ≥ 98.0% | HPLC |
| Molecular Weight | 309.27 g/mol | Theoretical |
| pH Value (1% water solution) | 1.8 – 2.5 | pH Meter |
| Heavy Metals (as Pb) | ≤ 10 ppm | ICP-MS |
| Residual Solvents | Meets EP/USP Limits (Ethanol ≤5000ppm) | GC-HS |
| Total Plate Count | ≤ 1,000 CFU/g | GB 4789.2 |
| Commercial Packaging | 1kg aluminum foil bag / 25kg fiber drum lined with double polyethylene bags | Industrial Standard |
| Shelf Life | 24 Months stored in sealed original containers below 25°C | Stability Testing |
Formulation & Processing Guidelines
- Recommended Dosage: Topical cosmetics: 0.2%–1.5%; Oral dietary supplements: 100mg–500mg daily allowance.
- Thermal Processing Tolerance: Stable up to 60°C for brief processing windows; cold-process addition below 40°C recommended for optimal preservation.
- pH Stability Range: Optimal formulation stability resides between pH 3.0 and 6.5. Adjust aqueous phase pH post-dissolution.
- Incorporation Phase: Pre-dissolve completely in purified water phase prior to emulsion blending or cold filling operations.
Logistics & Shipping Matrix
| Shipping Method | Suited Volume & Freight Cost | Logistics Service Details |
|---|---|---|
| Express (DHL/FedEx) | Low Volume (<50kg) | Higher unit cost | Door-to-Door priority delivery. Transit: 2–3 business days. Full temperature protection. |
| Air Freight | Medium Volume (50kg–500kg) | Balanced cost | Airport-to-Airport. Transit: 3–5 business days. Ideal for tight production schedules. |
| Sea Freight | Commercial Bulk (>500kg) | Lowest freight rate | Seaport-to-Seaport LCL/FCL. Transit: 15–30 days depending on port destination. Palletized. |
Technical & Commercial Advantages
NutraJagen brings more than 15 years of expertise in astaxanthin manufacturing and global supply, backed by a broad portfolio covering thousands of plant extract ingredients engineered for global distribution.
Natural Solutions: Focus on plant-based ingredients aligned with clean, sustainable, and health-oriented international concepts. Raw material sourcing adheres to traceable bio-fermentation protocols that reduce carbon footprints while maintaining high potency metrics.
Quality Management: In-house testing facility combined with independent third-party verification to ensure consistent batch compliance. Advanced HPLC, GC, and ICP-MS testing hardware eliminates off-spec raw materials long before global shipment dispatch.
Professional Team: Skilled commercial and technical teams providing proactive guidance and responsive R&D support. Direct communication bridges product development needs with manufacturing scheduling seamlessly.
Customer Support: End-to-end service team maintaining close follow-up from inquiry to delivery and beyond to ensure seamless cooperation. Custom documentation, rapid analytical verification, and regulatory file support remain accessible round-the-clock.
Frequently Asked Questions (B2B Commercial)
What is the Minimum Order Quantity (MOQ) for N-Acetylneuraminic Acid?
Standard commercial MOQ starts at 1 Kilogram packaged in sealed aluminum foil bags. Evaluation samples (10g–50g) are available for qualified laboratory R&D trials upon request.
What lead times apply for industrial bulk manufacturing orders?
Spot inventory quantities dispatch within 2 business days from order lock. Production runs exceeding 500 Kilograms require a standard manufacturing lead time of 7 to 10 working days.
How does Sialic Acid perform under elevated processing temperatures?
Sialic acid demonstrates high structural integrity up to 60°C. Prolonged heating above 80°C in strongly acidic aqueous media accelerates hydrolysis, warranting late-stage formulation introduction.
Which global compliance documents accompany every commercial batch?
Every shipment includes a lot-specific Certificate of Analysis (COA), Safety Data Sheet (MSDS), ISO22000/HACCP/HALAL certificates, Non-GMO statement, and Heavy Metal compliance reports.
Can NutraJagen accommodate customized packaging or particle micronization?
Yes. We support custom package sizes (e.g., 5kg, 10kg foil units), specific particle size tailoring (80-200 mesh), and custom OEM liquid precursor preparation under OEM service agreements.
Secure Direct Factory Pricing & COA Documentation
Access active bulk stock, request pilot lab testing samples, or schedule technical R&D consultation directly with our chemical engineering specialists.
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